Medical research

Increased flexibility seen in preapproval evidence for new drugs

The characteristics of acceptable preapproval evidence were more flexible for novel drugs approved by the U.S. Food and Drug Administration in 2020, according to a research letter published online May 17 in JAMA Network Open.

Diseases, Conditions, Syndromes

Plant-based recombinant COVID-19 vaccine found to be effective

Coronavirus-like particles (CoVLP), which are produced in plants, combined with an adjuvant (Adjuvant System 03 [AS03]) forms a candidate vaccine that is effective for preventing COVID-19, according to a study published online ...

Attention deficit disorders

Vitamins, minerals improve symptoms for children with ADHD

Children with ADHD and emotional dysregulation who were given a micronutrient-dense formula made of all known vitamins and essential minerals were three times more likely to have better concentration and improved moods, research ...

Medications

Fenfluramine seems effective for Lennox-Gastaut syndrome

Among patients with Lennox-Gastaut syndrome (LGS), the percentage reduction in the frequency of drop seizures is greater with fenfluramine versus placebo, according to a study published online May 2 in JAMA Neurology.

Obstetrics & gynaecology

RSV prefusion F protein-based immunization studied in pregnancy

A bivalent respiratory syncytial virus (RSV) prefusion F protein-based (RSVpreF) vaccine given during pregnancy elicits neutralizing antibody responses, according to a study published in the April 28 issue of the New England ...

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Placebo

A placebo is a sham medical intervention. In one common placebo procedure, a patient is given an inert sugar pill, told that it may improve his/her condition, but not told that it is in fact inert. Such an intervention may cause the patient to believe the treatment will change his/her condition; and this belief does indeed sometimes have a therapeutic effect, causing the patient's condition to improve. This phenomenon is known as the placebo effect.

Placebos are widely used in medicine, and the placebo effect is a pervasive phenomenon; in fact, it is part of the response to any active medication. However, the deceptive nature of the placebo creates tension between the Hippocratic Oath and the honesty of the doctor-patient relationship. The placebo effect points to the importance of perception and the brain's role in physical health.

Since the publication of Henry K. Beecher's The Powerful Placebo in 1955 the phenomenon has been considered to have clinically important effects. This view was notably challenged when in 2001 a systematic review of clinical trials concluded that there was no evidence of clinically important effects, except perhaps in the treatment of pain and continuous subjective outcomes. The article received a flurry of criticism, but the authors later published a Cochrane review with similar conclusions. Most studies have attributed the difference from baseline till the end of the trial to a placebo effect, but the reviewers examined studies which had both placebo and untreated groups in order to distinguish the placebo effect from the natural progression of the disease.

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