Periodontitis linked to HPV-positive head, neck tumors

June 20, 2012
Periodontitis linked to HPV-Positive head, neck tumors
For patients with head and neck squamous cell carcinoma there is an increased risk of human papillomavirus-positive tumors among those with a history of periodontitis, according to a study published online June 18 in the Archives of Otolaryngology -- Head & Neck Surgery.

(HealthDay) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published online June 18 in the Archives of Otolaryngology -- Head & Neck Surgery.

Mine Tezal, D.D.S., Ph.D., from the State University of New York at Buffalo, and colleagues evaluated dental records and tissue samples from 124 patients over the age of 21 years diagnosed with incident primary (SCC) of the oral cavity, oropharynx, and larynx between 1999 and 2007. Alveolar bone loss measured from panoramic radiographs was used to assess history, and the correlation between periodontitis and HPV status of HNSCC was evaluated.

The researchers found that the prevalence of HPV-positive HNSCC was 40.3 percent, with a higher proportion of oropharyngeal cancers HPV positive compared with oral cavity and laryngeal cancers (65.3 versus 29.0 and 20.5 percent, respectively). The odds of HPV-positive tumor status increased with each millimeter of alveolar bone loss (odds ratio [OR], 2.61), even after adjustment for age at diagnosis, sex, and smoking status. The odds of HPV-positive tumor status were greater among patients with oropharyngeal SCC (OR, 11.70), compared to those with oral cavity SCC (OR, 2.32; 95 percent confidence interval [CI], 0.65 to 8.27) and laryngeal SCC (OR, 3.89; 95 percent CI, 0.95 to 15.99).

"A history of chronic inflammatory disease in the oral cavity may be associated with tumor HPV status in patients with HNSCC," the authors write.

Explore further: Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers

June 18, 2012
Among patients with head and neck squamous cell carcinomas, a history of chronic inflammation in the mouth (periodontitis, i.e. gum disease) may be associated with an increased risk of tumors positive for human papillomavirus ...

Gender, insurance type tied to HPV infection in laryngeal cancer patients

September 14, 2011
The human papillomavirus (HPV) is more likely to be found in tumors of laryngeal cancer patients who are male and those with private health insurance, according to a new study from researchers at Henry Ford Hospital.

Oral HPV infection, HPV-related cancers more common in men

January 26, 2012
Oral HPV infection is more common among men than women, explaining why men are more prone than women to develop an HPV related head and neck cancer, according to a study presented at the Multidisciplinary Head and Neck Cancer ...

Recommended for you

Cancer-death button gets jammed by gut bacterium

July 27, 2017
Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy ...

Researchers release first draft of a genome-wide cancer 'dependency map'

July 27, 2017
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have identified more than 760 genes ...

Long-sought mechanism of metastasis is discovered in pancreatic cancer

July 27, 2017
Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power ...

Blocking the back-door that cancer cells use to escape death by radiotherapy

July 27, 2017
A natural healing mechanism of the body may be reducing the efficiency of radiotherapy in breast cancer patients, according to a new study.

Manmade peptides reduce breast cancer's spread

July 27, 2017
Manmade peptides that directly disrupt the inner workings of a gene known to support cancer's spread significantly reduce metastasis in a mouse model of breast cancer, scientists say.

Glowing tumor technology helps surgeons remove hidden cancer cells

July 27, 2017
Surgeons were able to identify and remove a greater number of cancerous nodules from lung cancer patients when combining intraoperative molecular imaging (IMI) - through the use of a contrast agent that makes tumor cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.