Potential biomarker emerging for diabetic neuropathy

June 13, 2012, University of New South Wales
Nervous system

An emerging biomarker may eventually lead to new approaches for treating diabetics at risk of developing nerve damage, UNSW researchers have found.

The researchers say neuropathy in is under-diagnosed and early identification has been problematic. It is estimated that up to 50 per cent of diabetics end up with nerve damage.

They tested excitability in diabetics with and without neuropathy and found those without irreversible still showed excitability abnormalities well before the development of clinical symptoms.

“Excitability testing provides a to identify the early development and severity of diabetic neuropathy,” the key researcher Dr Cindy Lin said.

The research was led by UNSW and the School of Medical Science’s Dr Cindy Lin and is published in the journal Diabetes.

Professor Matthew Kiernan from UNSW says the research may lead to new therapeutic approaches for treating patients with diabetic neuropathy early.

“It may yet prove possible to initiate therapy in diabetic patients well before they manifest the neurological symptoms and disability that inevitably reflects the presence clinical neuropathy,” Professor Kiernan says in his commentary, also published in Diabetes.

“Pharmacological manipulation of axonal membrane channels seems likely to provide further new therapeutic approaches for treating patients with diabetic neuropathy,” he says.

Explore further: To fix diabetic nerve damage, blood vessels and support cells may be the real targets of treatment

Related Stories

To fix diabetic nerve damage, blood vessels and support cells may be the real targets of treatment

June 23, 2011
Blood vessels and supporting cells appear to be pivotal partners in repairing nerves ravaged by diabetic neuropathy, and nurturing their partnership with nerve cells might make the difference between success and failure in ...

AAN issues new guideline on best treatments for diabetic nerve pain

April 11, 2011
The American Academy of Neurology has issued a new guideline on the most effective treatments for diabetic nerve pain, the burning or tingling pain in the hands and feet that affects millions of people with diabetes. The ...

Various metabolic risk factors could be linked to diabetes-related pain with major implications for treatment

May 17, 2012
Around 1 in 50 people in the general population and 1 in 6 of those aged over 40 years experience neuropathy (damage to the nerves of the peripheral nervous system), which can cause numbness, tingling, pain, or weakness. ...

Erectile dysfunction study shows high prevalence of peripheral neuropathy

November 15, 2011
Spanish researchers have uncovered clear links between erectile dysfunction (ED) and peripheral neuropathy, according to a paper in the December issue of the urology journal BJUI.

Diabetes: Tighter control of blood sugar prevents nerve condition, but at what risk?

June 12, 2012
Aggressive control of blood sugar levels in diabetes can help to prevent a painful condition affecting patients' nerves, according to a new systematic review in the Cochrane Library. However, the review suggests that optimal ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

Big strides made in diabetes care

January 5, 2018
(HealthDay)—This past year was a busy, productive one for diabetes research and care.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.