Psoriasis increases risk of diabetes: study

June 18, 2012, University of Pennsylvania School of Medicine

Psoriasis is an independent risk for Type 2 Diabetes, according to a new study by researchers with the Perelman School of Medicine at the University of Pennsylvania, with the greatest risk seen in patients with severe psoriasis. Researchers estimate that an additional 115,500 people will develop diabetes each year due to the risk posed by psoriasis above and beyond conventional risk factors. The research is published in the latest issue of the Archives of Dermatology.

"These data suggest that patients with psoriasis are at increased risk for developing diabetes even if they don't have common risk factors such as obesity," said senior author Joel M. Gelfand, MD, MSCE, associate professor of Dermatology in the Perelman School of Medicine. "Patients with psoriasis should eat a healthy diet, get regular exercise, and see their physician for routine preventative health screenings such as checks of blood pressure, cholesterol, and blood sugar."

Psoriasis is a common inflammatory skin disease affecting over 7.5 million Americans and causes thick, inflamed, scaly patches of skin. The disease has previously been associated with increased risk of , stroke, and .

"This research builds on previous work demonstrating a diverse set of increased health risks for people with psoriasis," said lead author Rahat S. Azfar, MD, MSCE, adjunct assistant professor of Dermatology in the Perelman School of Medicine. "In addition to having an increased risk of diabetes, people with psoriasis are more likely to have metabolic syndrome, high triglycerides, and raised , even if they are not overweight or have other common risk factors for these conditions. Both patients with psoriasis, especially those with severe psoriasis, and their treating physicians should be aware of the potential for systemic associated with this skin disease."

Both psoriasis and diabetes are diseases caused by . A shared pathway - TH-1 cytokines - can promote insulin resistance and metabolic syndrome, and promote inflammatory cytokines known to drive psoriasis.

The study compared 108,132 people with psoriasis to 430,716 matched patients without psoriasis, and determined patients with mild psoriasis had an 11% increased risk of diabetes and patients with severe psoriasis had a 46% higher risk compared to patients without psoriasis. The study also looked at treatments used by those diagnosed with diabetes, and found that the patients with both psoriasis and diabetes were more likely to require pharmacological treatment of diabetes, compared to diabetics without psoriasis.

Researchers noted that future studies should look into the extent to which psoriasis and its treatment play a role in the development of and its complications.

Explore further: Psoriasis patients may face higher heart risk

More information: Arch Dermatol. Published online June 18, 2012. doi:10.1001/archdermatol.2012.1401

Related Stories

Psoriasis patients may face higher heart risk

March 16, 2012
(HealthDay) -- People with the painful skin condition psoriasis may be at increased risk for health problems that affect the heart, an expert says.

Extremely obese children have higher prevalence of psoriasis, higher heart disease risk

May 18, 2011
Children who are overweight or obese have a significantly higher prevalence of psoriasis, and teens with psoriasis, regardless of their body weight, have higher cholesterol levels, according to a Kaiser Permanente study published ...

Psoriasis is associated with impaired HDL function

November 16, 2011
Collaborative research from Perelman School of Medicine at the University of Pennsylvania has shown that psoriasis patients have an increased risk of heart attack, stroke and cardiovascular death, especially if the psoriasis ...

Recommended for you

New strategy discovered toward possible prevention of cancers tied to mono, the 'kissing disease'

November 12, 2018
Researchers from the University of Minnesota, the Howard Hughes Medical Institute, and the University of Toronto have discovered a possible path forward in preventing the development of cancers tied to two viruses, including ...

Hepatitis C treatment can be shortened in 50 percent of patients, study finds

November 12, 2018
Hepatitis C drugs cure more than 90 percent of patients, but can cost more than $50,000 per patient.

Salmonella found to be resistant to different classes of antibiotics

November 12, 2018
Brazil's Ministry of Health received reports of 11,524 outbreaks of foodborne diseases between 2000 and 2015, with 219,909 individuals falling sick and 167 dying from such diseases. Bacteria caused most outbreaks of such ...

Combination therapy promising against blindness-causing bacterial keratitis

November 12, 2018
Multidrug-resistant bacterial infections of the cornea are a leading cause of blindness and cannot be effectively managed with current ophthalmic antibiotics. A team of investigators has now devised a combination therapy ...

To better treat COPD, scientists look to tailored approaches for deadly lung disease

November 9, 2018
Valerie Chang kept waking up breathless in the middle of the night. As a regular swimmer and non-smoker, she figured it was a fluke, a remnant of her childhood asthma, perhaps.

Anopheles mosquitoes could spread Mayaro virus in US, other diverse regions

November 9, 2018
Mosquitoes of the genus Anopheles are well known as primary vectors of malaria. But a new study suggests that Anopheles species, including some found in the United States, also are capable of carrying and transmitting an ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

joemostowey
not rated yet Jun 18, 2012
Dumkoffs!
Look at the gut bacteria! Look! Look! Bacteria are know to mimic neurotansmitters, which cause inflamation throughout the entire body. Both psoriasis and diabetes are results of a compromised immune system attacking the body itself due to the effect of these bogus neurotransmitters. Much of the guts' native bacteria are killed by the use of general antibiotics proscribed to cure something else. Some of the same bacteria that inhabits the mouth and gums are taking up residence in the gut, and in the cardiovascular system causing inflamation in the vessel walls as well as in the intestines- and without the native bateria to run interference (competition) they attempt to alter the host body to make it more hospitable for them.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.