Aspirin still first-line therapy for unstable angina/NSTEMI

July 17, 2012
Aspirin still first-line therapy for unstable angina/NSTEMI
Aspirin is still the first line of therapy for patients with unstable angina or non-ST-elevation myocardial infarction, and ticagrelor can be used in place of clopidogrel or prasugrel instead of aspirin or as a second antiplatelet agent, according to a report from the American College of Cardiology Foundation/American Heart Association published online July 16 in Circulation.

(HealthDay) -- Aspirin is still the first line of therapy for patients with unstable angina or non-ST-elevation myocardial infarction (NSTEMI), and ticagrelor can be used in place of clopidogrel or prasugrel instead of aspirin or as a second antiplatelet agent, according to a report from the American College of Cardiology Foundation (ACCF)/American Heart Association (AHA) published online July 16 in Circulation.

Hani Jneid, M.D., from the Baylor College of Medicine in Houston, and colleagues reviewed recent evidence to provide clinicians with a focused update on current guidelines for the management of patients with /NSTEMI. This report updates the 2007 guideline and replaces the 2011 focused update.

The authors recommend that aspirin still be regarded as the first line of therapy for patients with unstable angina/NSTEMI and should be administered as soon as possible after hospital presentation and maintained indefinitely as long as tolerated. Patients who are unable to take aspirin may receive prasugrel (percutaneous coronary intervention-treated patients), ticagrelor, or clopidogrel. Patients who undergo an invasive procedure and are at medium or high risk should receive dual antiplatelet therapy that includes aspirin and a second . Patients undergoing medical treatment alone should be given aspirin indefinitely and clopidogrel or ticagrelor for up to 12 months.

"The AHA and ACCF constantly update their guidelines so that physicians can provide patients with the most appropriate, aggressive therapy with the goal of improving health and survival," Jneid said in a statement. "While this focused update of the guidelines provides important guidance to clinicians, our recommendations are not substitutes for a physician's own clinical judgments and the tailoring of therapy based on individual variability and a patient's presentation and ."

Several members of the writing committee disclosed financial ties to the pharmaceutical industry.

Explore further: Updated AHA/ACCF guidelines for unstable angina include newest blood-thinning drug

More information: Full Text

Related Stories

Updated AHA/ACCF guidelines for unstable angina include newest blood-thinning drug

July 16, 2012
Ticagrelor, a blood-thinning drug approved by the FDA in 2011, should be considered along with older blood thinners clopidogrel and prasugrel for treating patients who are experiencing chest pain or some heart attacks, according ...

New study suggests potent antiplatelet drug effective with low-dose aspirin

June 27, 2011
When taken with higher doses of aspirin (more than 300 milligrams), the experimental antiplatelet drug ticagrelor was associated with worse outcomes than the standard drug, clopidogrel, but the opposite was true with lower ...

Increased risk of bleeding with combined use of SSRIs and antiplatelet therapy after heart attacks

September 26, 2011
Heart attack patients taking selective serotonin reuptake inhibitors (SSRIs) in combination with antiplatelet therapy -- acetylsalicylic acid (ASA), clopidogrel or both (dual antiplatelet therapy) -- are at higher risk of ...

Recommended for you

Early study shows shoe attachment can help stroke patients improve their gait

December 14, 2017
A new device created at the University of South Florida – and including a cross-disciplinary team of experts from USF engineering, physical therapy and neurology – is showing early promise for helping correct the signature ...

Scientists rewrite our understanding of how arteries mend

December 13, 2017
Scientists from The University of Manchester have discovered how the severity of trauma to arterial blood vessels governs how the body repairs itself.

Deadly heart rhythm halted by noninvasive radiation therapy

December 13, 2017
Radiation therapy often is used to treat cancer patients. Now, doctors at Washington University School of Medicine in St. Louis have shown that radiation therapy—aimed directly at the heart—can be used to treat patients ...

Ultra-thin tissue samples could help to understand and treat heart disease

December 12, 2017
A new method for preparing ultra-thin slices of heart tissue in the lab could help scientists to study how cells behave inside a beating heart.

Young diabetics could have seven times higher risk for sudden cardiac death

December 12, 2017
Young diabetics could have seven times more risk of dying from sudden cardiac arrest than their peers who don't have diabetes, according to new research.

Research reveals how diabetes in pregnancy affects baby's heart

December 12, 2017
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered how high glucose levels—whether caused by diabetes or other factors—keep heart cells from maturing ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.