Study shows why hypertension increases damage to eyes of diabetic patients

July 12, 2012

Hypertension frequently coexists in patients with diabetes. A new University of Georgia study shows why the co-morbid conditions can result in impaired vision.

"Results showed early signals of cell death in eyes from diabetic animals within the first six weeks of elevated blood pressure. Later, the tiny blood vessels around the that nourish the retina and affect visual processing showed signs of decay as early as 10 weeks after diabetic animals develop hypertension," said Azza El-Remessy, assistant professor in the UGA College of Pharmacy and director of the UGA clinical and experimental therapeutics program.

The study examined animals with early and established stages of diabetes that also had hypertension. The results, which highlight the importance of tight and to delay diabetes-related , were published in the June issue of the Journal of Molecular Vision. The study was the first to understand or explain why combining increased blood pressure with diabetes would hurt blood vessels in the eye.

"The fact that controlling blood pressure in diabetic patients is beneficial has been shown through many major clinical trials," said Islam Mohamed, a third-year clinical and experimental therapeutics graduate student who co-authored the paper with El-Remessy. "Our study highlights the synergistic and immediate interaction between systemic hypertension and diabetes as two independent risk factors for persistent retina damage known as retinopathy. This emphasizes the importance of addressing different in a holistic approach for improving management and prevention of retinopathy."

According to the , 45 percent of adults in the U.S. suffer from diabetes, hypertension or high levels of cholesterol in the blood called . Approximately 13 percent of U.S. adults suffer from a combination of two of the conditions, and 3 percent have all three.

Early intervention is a key factor in improving the outcome for patients.

"Health care providers, including pharmacists, should stress the importance of the tight control of blood sugar and blood pressure levels for their patients," El-Remessy said. "Providing patient education and counseling on how each of these metabolic problems independently can have accelerated devastating effects is critical and can result in better prevention and outcomes for the patients."

Explore further: Study focuses on relationship between glaucoma and diabetes, hypertension

More information: The entire journal article is available online at www.ncbi.nlm.nih.gov/pmc/artic … 3380918/?tool=pubmed

Related Stories

Study focuses on relationship between glaucoma and diabetes, hypertension

August 17, 2011
Many Americans suffer from diabetes and hypertension and, according to a study by researchers at the University of Michigan Kellogg Eye Center, these individuals may have an increased risk of developing open-angle glaucoma ...

Recommended for you

Personalized blood sugar goals can save diabetes patients thousands

December 11, 2017
A cost analysis by researchers at the University of Chicago Medicine shows treatment plans that set individualized blood sugar goals for diabetes patients, tailored to their age and health history, can save $13,546 in health ...

Kidney disease increases risk of diabetes, study shows

December 11, 2017
Diabetes is known to increase a person's risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of ...

Type 2 diabetes is not for life

December 5, 2017
Almost half of the patients with Type 2 diabetes supported by their GPs on a weight loss programme were able to reverse their diabetes in a year, a study has found.

Skipping breakfast disrupts 'clock genes' that regulate body weight

November 30, 2017
Irregular eating habits such as skipping breakfast are often associated with obesity, type 2 diabetes, hypertension and cardiovascular disease, but the precise impact of meal times on the body's internal clock has been less ...

Type 2 diabetes has hepatic origins

November 28, 2017
Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type ...

Critical link between obesity and diabetes has been identified

November 28, 2017
UT Southwestern researchers have identified a major mechanism by which obesity causes type 2 diabetes, which is a common complication of being overweight that afflicts more than 30 million Americans and over 400 million ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.