Pramlintide improves glucose control in type 1 diabetes

July 25, 2012
Pramlintide improves glucose control in type 1 diabetes
The addition of pramlintide, an analog of the naturally-occurring β-cell peptide amylin, before meals improves blood glucose control in patients with type 1 diabetes receiving insulin through an external closed-loop artificial pancreas system, according to a study published online June 18 in Diabetes Care.

(HealthDay) -- The addition of pramlintide, an analog of the naturally-occurring β-cell peptide amylin, before meals improves blood glucose control in patients with type 1 diabetes receiving insulin through an external closed-loop artificial pancreas system, according to a study published online June 18 in Diabetes Care.

To examine whether preprandial injections of pramlintide would improve postprandial glycemia by delaying gastric emptying, Stuart A. Weinzimer, M.D., from the Yale University School of Medicine in New Haven, Conn., and colleagues treated eight patients with type 1 diabetes (15 to 30 years old) with a closed-loop delivery system for 24 hours either alone or plus preprandial injections of 30 µg pramlintide.

The researchers found that the addition of pramlintide significantly increased the mean time to peak (2.5 versus 1.5 hours). The addition of pramlintide also significantly reduced the mean magnitude of glycemic excursion (88 versus 113 mg/dL), with the reduction being particularly pronounced at lunch and dinner, when premeal insulin concentrations were higher.

"Pramlintide delayed the time to peak postprandial blood glucose and reduced the magnitude of prandial blood glucose excursions," Weinzimer and colleagues conclude. "Beneficial effects of pramlintide on closed-loop may in part be related to higher premeal insulin levels at lunch and dinner compared with breakfast."

Two authors are employees of Medtronic , which provided equipment for the study. Two additional authors are consultants/advisors to Medtronic MiniMed and Animas Corporation.

Explore further: Artificial pancreas may improve overnight control of diabetes in adults

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Artificial pancreas may improve overnight control of diabetes in adults

April 15, 2011
Two small randomised trials published in the British Medical Journal today suggest that closed loop insulin delivery (also known as an artificial pancreas) may improve overnight blood glucose control and reduce the risk of ...

ADA: Hypo-hyperglycemia minimizer system feasible

June 12, 2012
(HealthDay) -- The hypoglycemia-hyperglycemia minimizer (HHM) system, which includes a continuous, subcutaneous insulin infusion pump, continuous glucose monitor (CGM), and software, is able to predict changes in blood glucose ...

Mayo Clinic developing artificial pancreas to ease diabetes burden

June 24, 2011
The 25.8 million Americans who have diabetes may soon be free of finger pricks and daily insulin dosing. Mayo Clinic endocrinologists Yogish Kudva, M.B.B.S., and Ananda Basu, M.B.B.S., M.D., are developing an artificial pancreas ...

Absolute incretin effect reduced in type 2 diabetes

June 25, 2012
(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase insulin secretion, ...

Study suggests drug significantly improves glycemic control in type one diabetics on insulin

June 15, 2011
Results of a small, observational study conducted at the University at Buffalo suggest that liraglutide, an injectable medication used to treat type 2 diabetes, also helps type 1 diabetics on insulin achieve optimal control ...

Recommended for you

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

Immune system killer cells increase risk of diabetes

July 6, 2017
More than half of the German population is obese. One effect of obesity is to chronically activate the immune system, placing it under continuous stress. Researchers in Jens Brüning's team at the Max-Planck-Institute for ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.