Three SNPs linked to aortic stenosis in older adults

July 6, 2012
Three SNPs linked to aortic stenosis in older adults
Three single nucleotide polymorphisms are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal of Cardiology.

(HealthDay) -- Three single nucleotide polymorphisms (SNPs) are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal of Cardiology.

Stephen G. Ellis, M.D., from the Cleveland Clinic, and colleagues genotyped 265 patients (aged 73 ± 7 years; 72.7 percent male) with aortic stenosis involving tricuspid and 961 controls (69 ± 6 years; 69.8 percent male) for up to 660 candidate . The correlation between age-adjusted aortic valve area, as determined by echocardiography or cardiac catheterization, and SNPs was assessed, with a bootstrapped global P value of ≤0.005 indicative of a possible significant correlation.

The researchers found that minor allele frequency was 21 percent ± 15 percent. The criteria for a significant correlation were met by three SNPs (rs2276288 [MYO7A], P = 0.001; rs5194 [AGTR1], P = 0.004; rs207 307 [ELN], P = 0.005). Two additional SNPs achieved borderline significance (P ≤0.008).

"In conclusion, we report three SNPs to be associated with aortic stenosis involving tricuspid aortic valves in older subjects," the authors write. "Given the concerns regarding the problem of multiple statistical testing, validation studies are required to further assess these correlations."

Explore further: Gender differences in clinical presentation and outcome of transcatheter aortic valve implantation

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Gender differences in clinical presentation and outcome of transcatheter aortic valve implantation

August 29, 2011
Severe aortic stenosis (AS) is increasing in frequency as the population ages. For a subset of patients in whom surgical conventional aortic valve replacement is excluded due to severe co-morbidities, an alternative to surgical ...

Transcatheter aortic valve implantation shows promise in patients with severe aortic stenosis

April 10, 2012
German researchers report success with transcatheter aortic valve implantation (TAVI) in patients with low-flow, low-gradient aortic stenosis—a special form of aortic stenosis that is difficult to treat. Results published ...

Recommended for you

Researchers borrow from AIDS playbook to tackle rheumatic heart disease

January 22, 2018
Billions of US taxpayer dollars have been invested in Africa over the past 15 years to improve care for millions suffering from the HIV/AIDS epidemic; yet health systems on the continent continue to struggle. What if the ...

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

nanotech_republika_pl
not rated yet Jul 06, 2012
23andme ver. 3 chip provides information about 2 of those listed SNPs.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.