A weak heart produces a poor appetite

July 12, 2012, Medical University of Vienna

Heart-brain-stomach link of major importance for diabetes and heart failure discovered: as a recent study by the MedUni Vienna has demonstrated, the hormone BNP, generated by the heart, also has an appetite-inhibiting effect. This discovery may open up new therapeutic opportunities for people with chronic heart failure or diabetes.

The heart not only responds to hormones, but it also produces some of these messenger substances itself. In patients with heart failure (weak hearts), increased levels of the BNP (B-type natriuretic peptide) are released. When produced in greater quantities, this hormone supports the heart’s action: not only do the kidneys excrete more sodium and fluid, but the vessels also dilate. The clear relationship between chronic and loss of appetite and the dramatic loss of weight was already known about, and determining the reason behind it would represent an important new discovery.

“Heart hormone” BNP has an appetite-suppressing effect

A team at the MedUni Vienna led by Martin Clodi from the Clinical Department of Endocrinology and Metabolic Diseases has now been able to answer this question. The hormone BNP is the culprit, since it has a direct -suppressing effect. The mechanism behind it is also described by the study, which has just been published in the internationally leading magazine “Diabetes”.

Newly-discovered “heart-brain-stomach link” opens up new therapeutic possibilities

Until now, all that was known was that there was a bi-directional connection between the brain and the gastrointestinal tract. This “brain- link” is also one of the key triggers for the chronic conditions of irritable bowel syndrome and dyspepsia. “The heart-brain-stomach link that has now been discovered apparently appears to exchange vital information with the brain and regulate key physical functions and, in , clearly makes it easier for the heart to work effectively by reducing the patient's weight. This will open up interesting perspectives for new treatment concepts in and diabetes," says Clodi.

Explore further: Peptide level ups diagnosis of heart failure in primary care

More information: B-type natriuretic peptide modulates ghrelin, hunger and satiety in healthy men. Vila G, Grimm G, Resl M, Heinisch BB, Einwallner E, Esterbauer H, Dieplinger B, Mueller T, Luger A, Clodi M. Diabetes, June 14, 2012, doi: 10.2337/db11-1466

Related Stories

Peptide level ups diagnosis of heart failure in primary care

May 15, 2012
(HealthDay) -- For patients presenting with dyspnea, the additional measurement of B-type natriuretic peptide (BNP) levels increases the certainty of diagnosis of heart failure and accelerates initiation of appropriate treatment, ...

One cause of fatty deposits in the hearts of diabetes patients settled

April 16, 2012
The impaired substrate metabolism of diabetes patients is often expressed in an increase in fatty deposits in the cells of the heart muscle. Until now, the exact cause of this was unknown. Now, Austrian researchers at the ...

Heart failure linked to thinner bones and fractures

February 2, 2012
Heart failure is associated with a 30 percent increase in major fractures and also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis, according to a recent study accepted ...

Recommended for you

A novel insulin accelerant

October 17, 2018
Insulin levels rise after eating a meal, signaling uptake of circulating glucose by skeletal muscle. In individuals with diabetes this process is often impaired—a condition known as insulin resistance.

Fat tissue may play a crucial role in the progression of diabetes, challenging long established notions

October 12, 2018
A new study by Australian researchers, out today, is challenging what we know about the causes of diabetes. The new research points to fat tissue as a source of disease, and widens our understanding beyond the traditional ...

Does breastfeeding hormone protect against type 2 diabetes?

October 12, 2018
(HealthDay)—The hormone prolactin—most commonly associated with breastfeeding—may play a role in reducing the risk of type 2 diabetes, a new study suggests.

Planned intermittent fasting may help reverse type 2 diabetes, suggest doctors

October 10, 2018
Planned intermittent fasting may help to reverse type 2 diabetes, suggest doctors writing in the journal BMJ Case Reports after three patients in their care, who did this, were able to cut out the need for insulin treatment ...

Markers of dairy fat consumption linked to lower risk of type two diabetes

October 10, 2018
Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken ...

New discovery restores insulin cell function in type 2 diabetes

October 8, 2018
By blocking a protein, VDAC1, in the insulin-producing beta cells, it is possible to restore their normal function in case of type 2 diabetes. In preclinical experiments, the researchers behind a new study have also shown ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.