Efficacy of LCZ696 in patients with heart failure and preserved ejection fraction

August 27, 2012

The novel angiotensin receptor neprilysin inhibitor, LCZ696, demonstrated beneficial effects in heart failure patients with preserved ejection fraction (HFpEF), according to results of the PARAMOUNT (Prospective compArison of ARNI with ARB on Management Of heart failUre with preserved ejectioN fracTion) trial.

Approximately half of all have normal or nearly normal , a measure of their strength of cardiac contraction. However, while many studies have shown a benefit of pharmacological therapies in with reduced ejection fraction, so far, according to the latest ESC heart failure guidelines, no treatment has been shown to reduce mortality or morbidity in HFpEF.

The PARAMOUNT study, a phase II trial conducted in 308 in 13 countries, compared the effects of LCZ696, a new angiotensin receptor neprilysin inhibitor, and the ARB valsartan on the concentrations of natriuretic peptides. The investigated in this study, NT-proBNP, is a marker of cardiac wall stress, and levels are increased in .

Study results presented here today showed that LCZ696 reduced levels of NT-proBNP by 23% when compared with valsartan. LCZ696 also reduced enlargement of the , another marker of adverse outcomes in heart failure, and improved the symptoms of heart failure.

According to the study's lead author Professor Scott Solomon, Professor of Medicine at Harvard Medical School and Director of Noninvasive Cardiology at Brigham and Women's Hospital, Boston, LCZ696 acts by inhibiting both the angiotensin receptor and the enzyme responsible for the breakdown of the natriuretic peptides (neprilysin). LCZ696's dual mechanism of action thus acts to restore the altered neurohormonal balance in HFpEF. Earlier research has suggested that the clinical benefits derived from neprilysin inhibition may be best achieved if the renin-angiotensin system is simultaneously inhibited.

"LCZ696 is unique in simultaneously blocking the renin angiotensin system while augmenting the body's intrinsic natriuretic peptide system through neprilysin inhibition," said Professor Solomon. "These dual effects may be important in the treatment of HFpEF.

"LCZ696 in the PARAMOUNT study is the first compound to show both reductions in NT-proBNP and left atrial size in HFpEF patients, each powerful predictors of outcome in heart failure. The favorable effects of LCZ696 seen in patients with HFpEF in PARAMOUNT are encouraging, and further testing of this agent in this patient population is warranted."

Explore further: Risk of death from heart failure is lower in women than in men

Related Stories

Risk of death from heart failure is lower in women than in men

March 8, 2012
Women with chronic heart failure survive longer than their male counterparts, according to a large analysis of studies comprising data on more than 40,000 subjects. The analysis represents the largest assessment of gender ...

Biomarker-guided heart failure treatment significantly reduces complications

October 17, 2011
Adding regular testing for blood levels of a biomarker of cardiac distress to standard care for the most common form of heart failure may significantly reduce the incidence of cardiovascular complications, a new study finds. ...

Hospital survival differs among Hispanic and non-Hispanic heart failure patients

March 13, 2012
The odds of surviving their hospital stay for heart failure differ between Hispanic and non-Hispanic white patients according to their level of heart function, even when they received equal care in hospitals participating ...

Certain biomarkers appear to increase risk of death for elderly patients with heart failure symptoms

May 24, 2011
Elderly patients with symptoms of heart failure and increased concentrations in the blood of the biomarker copeptin, or a combination of elevated concentrations of copeptin and the biomarker NT-proBNP, had an associated increased ...

Recommended for you

Early study shows shoe attachment can help stroke patients improve their gait

December 14, 2017
A new device created at the University of South Florida – and including a cross-disciplinary team of experts from USF engineering, physical therapy and neurology – is showing early promise for helping correct the signature ...

Scientists rewrite our understanding of how arteries mend

December 13, 2017
Scientists from The University of Manchester have discovered how the severity of trauma to arterial blood vessels governs how the body repairs itself.

Deadly heart rhythm halted by noninvasive radiation therapy

December 13, 2017
Radiation therapy often is used to treat cancer patients. Now, doctors at Washington University School of Medicine in St. Louis have shown that radiation therapy—aimed directly at the heart—can be used to treat patients ...

Ultra-thin tissue samples could help to understand and treat heart disease

December 12, 2017
A new method for preparing ultra-thin slices of heart tissue in the lab could help scientists to study how cells behave inside a beating heart.

Young diabetics could have seven times higher risk for sudden cardiac death

December 12, 2017
Young diabetics could have seven times more risk of dying from sudden cardiac arrest than their peers who don't have diabetes, according to new research.

Research reveals how diabetes in pregnancy affects baby's heart

December 12, 2017
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered how high glucose levels—whether caused by diabetes or other factors—keep heart cells from maturing ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.