Experimental combo treatment worsens type 1 diabetes

August 24, 2012
Experimental combo treatment worsens type 1 diabetes
A treatment regimen that is effective in preventing diabetes in a mouse model of the disease leads to worsening disease in patients with type 1 diabetes, according to a study published online June 20 in Diabetes.

(HealthDay)—A treatment regimen that is effective in preventing diabetes in a mouse model of the disease leads to worsening disease in patients with type 1 diabetes, according to a study published online June 20 in Diabetes.

Following up on previous results in a mouse model of autoimmune diabetes showing that treatment with and interleukin-2 (IL-2) prevented the disease, S. Alice Long, Ph.D., from the Benaroya Research Institute in Seattle, and colleagues performed a phase I trial of oral rapamycin (daily for three months) and subcutaneous IL-2 (three times per week for one month) in nine patients with type 1 diabetes.

The researchers observed a transient worsening of diabetes (based on metabolic and clinical data) and β-cell function (based on C-peptide levels) in all subjects. There was a transient increase in the levels of regulatory T cells, but also an increase in and eosinophils. The frequencies of effector T-cell subsets were not affected.

"Thus, rapamycin/IL-2 therapy boosted , but also promoted a proinflammatory environment that may have resulted in transient β-cell dysfunction," Long and colleagues conclude. "Such results highlight the difficulties in translating therapies to the clinic and emphasize the importance of broadly interrogating the immune system to evaluate the effects of therapy."

Glucometers and test strips were donated by LifeScan. One author disclosed financial interests in Novartis.

Explore further: Oxygen treatment beneficial in diabetes-prone mice

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Oxygen treatment beneficial in diabetes-prone mice

May 8, 2012
(HealthDay) -- Hyperbaric oxygen treatment of a preclinical diabetes mouse model reduces the incidence of diabetes and preserves insulin-producing β-cells, according to a study published online May 7 in Diabetes.

Turmeric component reduces type 2 diabetes incidence

July 12, 2012
(HealthDay) -- A component of turmeric -- curcumin -- reduces the incidence of type 2 diabetes and improves β-cell function in adults with prediabetes, according to a study published online July 6 in Diabetes Care.

Antibodies reverse type 1 diabetes in new immunotherapy study

July 5, 2012
Scientists at the University of North Carolina School of Medicine have used injections of antibodies to rapidly reverse the onset of Type I diabetes in mice genetically bred to develop the disease. Moreover, just two injections ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.