Nutrition type affects endocrinology in SGA infants

August 1, 2012
Nutrition type affects endocrinology in SGA infants
Small-for-gestational-age (SGA) infants who are formula-fed have elevated endocrine levels of high-molecular-weight adiponectin and insulin growth factor-I compared with breastfed SGA infants, according to research published in the August issue of Diabetes.

(HealthDay) -- Small-for-gestational-age (SGA) infants who are formula-fed (FOF) have elevated endocrine levels of high-molecular-weight (HMW) adiponectin and insulin growth factor-I (IGF-I) compared with breastfed (BRF) SGA infants, according to research published in the August issue of Diabetes.

Francis de Zegher, M.D., of the University of Leuven in Belgium, and colleagues conducted a study comparing 72 control infants born appropriate-for-gestational-age with 46 BRF and 56 FOF infants who had been born SGA. FOF infants received either standard formula or -rich formula. At birth and at 4 months of age, and HMW adiponectin and IGF-I levels were measured.

In the first four months, the researchers found that the SGA infants catch-up growth was primarily confined to lean mass, regardless of whether the infant was BRF or received formula. SGA-BRF infants had normal HMW adiponectin and IGF-I levels compared with BRF infants born appropriate-for-gestational-age. In contrast, SGA-FOF infants had increased HMW (particularly after receiving standard formula) and increased levels of IGF-I (particularly after receiving protein-rich formula).

"In conclusion, neonatal nutrition seems to influence endocrinology more readily than body composition of SGA infants," the authors write. "Follow-up will disclose whether the endocrine abnormalities in SGA-FOF infants can serve as early markers of an unfavorable metabolic course and whether they may contribute to design early interventions that prevent subsequent disease, including ."

Explore further: Early nutrition has a long-term metabolic impact

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Early nutrition has a long-term metabolic impact

May 2, 2011
Nutrition during the first days or weeks of life may have long-term consequences on health, potentially via a phenomenon known as the metabolic programming effect, according to a study to be presented Monday, May 2, at the ...

PUFA formula supplementation doesn't up infant cognition

May 29, 2012
(HealthDay) -- Supplementation of infant formula with long-chain polyunsaturated fatty acids (LCPUFAs) is not associated with improved cognition; and infants fed with milk- or soy protein-based formula have similar cognitive ...

Delivery of a small full-term infant puts mothers at risk for heart disease

March 14, 2012
Delivering a full-term baby of small birth weight has been shown to be an independent indicator of later heart disease for the mother, and as equivalent in risk as high blood pressure and diabetes. Researchers at the University ...

New infant formula ingredients boost babies' immunity by feeding their gut bacteria

February 29, 2012
Adding prebiotic ingredients to infant formula helps colonize the newborn's gut with a stable population of beneficial bacteria, and probiotics enhance immunity in formula-fed infants, two University of Illinois studies report.

Recommended for you

Researchers discover link between gut and type 1 diabetes

February 19, 2018
Scientists have found that targeting micro-organisms in the gut, known as microbiota, could have the potential to help prevent type 1 diabetes.

Researchers find existing drug effective at preventing onset of type 1 diabetes

February 15, 2018
A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 percent of those at risk for the disease, according to researchers at the University of Colorado Anschutz ...

Chemist designs diabetic treatment minus harmful side effects

February 9, 2018
A chemist in the College of Arts and Sciences (A&S) has figured out how to control glucose levels in the bloodstream without the usual side effects of nausea, vomiting or malaise.

Peptide improves glucose and insulin sensitivity, lowers weight in mice

February 8, 2018
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School ...

Study reports use of nutritional ketosis with mobile app intervention could reverse Type 2 diabetes

February 7, 2018
A newly published study has shown that an individualized approach to nutritional ketosis (utilizing fat rather than glucose to fuel the body), combined with remote monitoring via a mobile application, could sustainably and ...

Simple molecule could prevent, alleviate pre-diabetes

February 7, 2018
Restoring levels of coenzyme Q10 (CoQ), a key molecule in energy production in cells, could overcome insulin resistance or pre-diabetes—a precursor to type 2 diabetes and cardiovascular disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.