Soy linked to exacerbated congenital hypothyroidism

August 20, 2012
Soy linked to exacerbated congenital hypothyroidism
Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 in Pediatrics.

(HealthDay) -- Soy products appear to interfere with levothyroxine absorption and can exacerbate congenital hypothyroidism in infants and young children, according to a case report published online Aug. 20 in Pediatrics.

Abigail Gelb Fruzza, M.D., from the University of California San Diego in La Jolla, and colleagues observed two with who continued to manifest clinical while receiving recommended doses of hormone and ingesting soy products.

The researchers found that the first patient (diagnosed by newborn screening showing thyroid-stimulating hormone [TSH] of 169 µIU/mL and treated with 50 µg of since 6 days of age while simultaneously starting soy formula) was clinically and biochemically hypothyroid (thyroxine, 4.0 µg/dL; TSH, 216 µIU/mL) at 3 weeks of age. After stopping her soy formula and decreasing her levothyroxine, signs of hypothyroidism had begun resolving three weeks later. By 10 weeks of age, she was clinically and biochemically euthyroid. Another patient, diagnosed by , received levothyroxine and did well; however, over the next two years she began consuming soy milk and became profoundly hypothyroid (free thyroxine, <0.4 ng/dL; TSH, 248 µIU/mL), even with an increase in her levothyroxine dose to 112 µg/day. After switching to cow milk, her thyroid function slowly normalized with decreasing doses of levothyroxine.

"These two patients reinforce the importance of remembering that soy products interfere with levothyroxine absorption and can endanger infants and young children with congenital hypothyroidism who are at risk for developmental and growth delay," the authors write.

Explore further: Concern over 'excessive' doses of thyroid drugs for older patients

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Concern over 'excessive' doses of thyroid drugs for older patients

April 29, 2011
Many older adults may be taking "excessive" doses of drugs for thyroid problems which can lead to an increased risk of fractures, finds a study published in the British Medical Journal today.

New study associates excess maternal iodine supplementation with congenital hypothyroidism

July 26, 2012
Congenital hypothyroidism is thyroid hormone deficiency at birth that, if left untreated, can lead to neurocognitive impairments in infants and children. Although the World Health Organization recommends 200-300 µg of ...

Treatment of subclinical hypothyroidism linked with fewer ischemic heart events in younger patients

April 23, 2012
Treatment of subclinical hypothyroidism with the medication levothyroxine appears to be related to fewer ischemic heart disease events in younger patients but this finding was not evident in older patients, according to a ...

Antenatal thyroid screening fails to improve IQ in 3-year-olds

February 8, 2012
Children of mothers screened and treated for reduced thyroid function during pregnancy show no signs of improved IQ compared to women who receive no treatment, new research has uncovered.

Harmful effects of hypothyroidism on maternal and fetal health drive new guidelines for managing thyroid disease in preg

July 25, 2011
Emerging data clarifying the risks of insufficient thyroid activity during pregnancy on the health of the mother and fetus, and on the future intellectual development of the child, have led to new clinical guidelines for ...

Recommended for you

Small drop in measles vaccinations would have outsized effect, study estimates

July 24, 2017
Small reductions in childhood measles vaccinations in the United States would produce disproportionately large increases in the number of measles cases and in related public health costs, according to a new study by researchers ...

At the cellular level, a child's loss of a father is associated with increased stress

July 18, 2017
The absence of a father—due to incarceration, death, separation or divorce—has adverse physical and behavioral consequences for a growing child. But little is known about the biological processes that underlie this link ...

New comparison chart sheds light on babies' tears

July 10, 2017
A chart that enables parents and clinicians to calculate if a baby is crying more than it should in the first three months of its life has been created by a Kingston University London researcher, following a study of colic ...

Blood of SIDS infants contains high levels of serotonin

July 3, 2017
Blood samples from infants who died of Sudden Infant Death Syndrome (SIDS) had high levels of serotonin, a chemical that carries signals along and between nerves, according to a study funded in part by the National Institutes ...

Is your child's 'penicillin allergy' real?

July 3, 2017
(HealthDay)—Many children suspected of being allergic to the inexpensive, first-line antibiotic penicillin actually aren't, new research indicates.

Probiotic supplements failed to prevent babies' infections

July 3, 2017
(HealthDay)—Probiotic supplements may not protect babies from catching colds or stomach bugs in day care, a new clinical trial suggests.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.