Study implicates marijuana use in pregnancy problems

September 12, 2012, Cincinnati Children's Hospital Medical Center

New research indicates marijuana-like compounds called endocannabinoids alter genes and biological signals critical to the formation of a normal placenta during pregnancy and may contribute to pregnancy complications like preeclampsia.

A study in the Sept. 14 edition of The offers new evidence that abnormal biological signaling by endocannabinoid produced by the body disrupts the movement of early embryonic cells important to a healthy pregnancy, in particular trophoblast cells that form the placenta. Abnormal placental function is common in preeclampsia – a medical condition of unknown cause that is a danger to mother and child.

The research – from scientists in the Division of Reproductive Sciences at Cincinnati Children's Hospital Medical Center – analyzed mouse preimplantation embryos mutated to alter endocannabinoid signaling. They found that either silencing or enhancing endocannabinoid signaling adversely affects trophoblast stem cell migration.

"The findings or our investigation raise concerns that exposure to cannabis products may adversely affect early embryo development that is then perpetuated later in pregnancy," said Sudhansu K. Dey, PhD., principal investigator on the study and division director. "Also, given that endocannabinoid signaling plays a key role in the , it would be interesting in future studies to examine whether affected cell migration-related genes in early embryos also participate in neuronal during brain development."

Along with co-first authors Huirong Xie and Xiaofei Sun, Dey and other members of the research team studied mouse embryos that had not yet implanted inside the uterus of the mother. Previous research by Dey's laboratory has shown the timing of critical events in , including when and how well an in the uterus, is vital to a healthy pregnancy and birth.

In the current study, researchers conducted analyses to determine how the expression levels of genes important to healthy embryo development were affected in embryos with abnormal endocannabinoid signaling.

In one group of embryos endocannabinoid signaling was silenced by deleting the gene Cnr1, which activates endocannabinoid signaling processes. A second group of mice was mutated to produce elevated endocannabinoid levels similar to that observed in wild type mice treated with tetrahydrocannabinol (THC), the active psychotropic agent in cannabis. This was done by deleting the gene Faah, which breaks down molecules that activate endocannabinoid signaling.

In both groups, the expression of numerous genes known to be important to cell movement and embryo development was lower than in normal wild type mice. This included the development and migration of trophoblast stem cells. Trophoblast cells help anchor the conceptus with the uterus and also form much of the placenta, critical to establishment of maternal-fetal circulation and exchange of nutrients.

Researchers said mouse models developed for the current study (with silenced and elevated endocannabinoid signaling) may help advance more extensive studies on the causes of preeclampsia.

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rfw
not rated yet Sep 12, 2012
Yes, obviously people should treat reproduction and child rearing with respect and undertake it as drug- and pollution-free as possible.

Educating everyone about proper preparation for and the context within which drug use is appropriate will save lives. Adults wishing to alter their states should be issued licenses for doing so, call them psychonaut licenses, much like driver's licensing for automobiles, with requirements for affordable insurance against misbehaviors such as DUI, etc. Blood chemistry, metabolic health screening and genetic analysis genetic analysis could contribute to rational, data-driven counseling about which substances are known to be exceptionally un-safe for any given individual. PROBLEM SOLVED.

Want to create a problem? Declare a "Drug War". Prohibition insures ignorance and access to impure substances thus creating victims, criminals, victimless crimes and overloaded prisons with people who do not belong there!!!

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