Study looks at pain processing abnormalities in knee OA

September 17, 2012
Study looks at pain processing abnormalities in knee OA
For patients with knee osteoarthritis, the lack of correlation between clinical pain and radiographic evidence of disease severity may be due to central sensitization, according to a study published online Sept. 7 in Arthritis & Rheumatism.

(HealthDay)—For patients with knee osteoarthritis (K-OA), the lack of correlation between clinical pain and radiographic evidence of disease severity may be due to central sensitization, according to a study published online Sept. 7 in Arthritis & Rheumatism.

Patrick H. Finan, Ph.D., from Johns Hopkins University in Baltimore, and colleagues conducted a study involving 113 participants with K-OA (67 percent women; mean age, 61.05 ± 8.93 years). The Kellgren-Lawrence scale was used to grade radiographic joint pathology. Quantitative sensory testing, including heat and pressure threshold, tonic suprathreshold pain (cold pressor test), and repeated phasic suprathreshold mechanical and thermal pain were used to index central sensitization. Patients were stratified into four groups based on clinical knee pain and knee grade scores: Low Pain/Low Knee Grade (24 participants), High Pain/Low Knee Grade (30), Low Pain/High Knee Grade (27), and High Pain/High Knee Grade (32).

The researchers found that the Low Pain/High Knee Grade group was less pain sensitive, while the High Pain/Low Knee Grade group had significantly heightened pain sensitivity. These differences persisted even after adjustment for differences on psychosocial measures, age, sex, and race.

"We have identified a subgroup of K-OA patients who display abnormalities in pain processing consistent with central sensitization, as well as a subgroup of patients who may be resilient to these abnormalities despite prominent joint degeneration," the authors write. "The findings provide support for the notion that central sensitization is an endophenotype for chronic pain in K-OA and contribute to the ongoing debate surrounding the variable association of clinical pain and radiographic severity of K-OA pathology."

Explore further: Lower back and foot pain associated with more severe knee osteoarthritis symptoms

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Lower back and foot pain associated with more severe knee osteoarthritis symptoms

November 17, 2010
A new study found that patients with osteoarthritis (OA) of the knee who also have pain in other joints were more likely to experience greater knee pain. Specifically, pain in the lower back as well as foot pain and elbow ...

BMI, post-exercise knee laxity change tied to OA progression

August 21, 2012
(HealthDay) -- In patients with osteoarthritis (OA) of the knee, changes in knee joint laxity during stair climbing or other repetitive physical activity and baseline body mass index (BMI) are associated with disease progression, ...

Knee pain common complaint in middle-aged and mature women

December 19, 2011
New research shows 63% of women age 50 and older reported persistent, incident, or intermittent knee pain during a 12-year study period. Predictors for persistent pain included higher body mass index (BMI), previous knee ...

Weight loss improves knee pain from common arthritic condition, study says

February 19, 2011
Knee pain related to osteoarthritis (OA) is a common complaint among obese individuals and retired professional athletes, especially former NFL players, but researchers presenting their work at the American Orthopaedic Society ...

Walking speed is a marker for knee osteoarthritis

March 20, 2012
(HealthDay) -- Slower walking speed may be a marker for identifying those at risk for knee osteoarthritis (OA), according to a study published online March 5 in Arthritis Care & Research.

Greater quadriceps strength may benefit those with knee osteoarthritis

January 13, 2009
Studies on the influence of quadriceps strength on knee osteoarthritis (OA), one of the leading causes of disability among the elderly, have shown conflicting results. In some studies, decreased quadriceps strength is associated ...

Recommended for you

How the brain plays a role in rheumatoid arthritis inflammation

June 18, 2018
In patients with chronic inflammatory conditions, such as rheumatoid arthritis, there has been limited understanding of how this inflammation affects the brain.

New 3-D imaging analysis technique could lead to improved arthritis treatment

June 18, 2018
An algorithm to monitor the joints of patients with arthritis, which could change the way that the severity of the condition is assessed, has been developed by a team of engineers, physicians and radiologists led by the University ...

Joint resolution: A link between Huntington's disease and rheumatoid arthritis

May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common ...

Get off the golf cart if you have knee osteoarthritis

April 28, 2018
From presidents to retirees, more than 17 million people over the age of 50 golf regularly. Knee osteoarthritis, which causes swelling, pain and difficulty moving the joint, is one of the leading causes of disability in this ...

How environmental pollutants and genetics work together in rheumatoid arthritis

April 19, 2018
It has been known for more than three decades that individuals with a particular version of a gene—human leukocyte antigen (HLA)—have an increased risk for rheumatoid arthritis.

The bugs in your gut could make you weak in the knees

April 19, 2018
Bacteria in the gut, known as the gut microbiome, could be the culprit behind arthritis and joint pain that plagues people who are obese, according to a new study published today in JCI Insight.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.