Genetic predisposition to diabetes ups risk of CVD

October 23, 2012
Genetic predisposition to diabetes ups risk of CVD
For patients with type 2 diabetes, having a genetic predisposition towards the disease is associated with an increased risk of cardiovascular disease, according to a study published online Oct. 15 in Diabetes Care.

(HealthDay)—For patients with type 2 diabetes (T2D), having a genetic predisposition towards the disease is associated with an increased risk of cardiovascular disease (CVD), according to a study published online Oct. 15 in Diabetes Care.

Qibin Qi, Ph.D., from the Harvard School of Public Health in Boston, and colleagues analyzed data from 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 with CVD and 1,645 control subjects without CVD. On the basis of 36 established independent diabetes-predisposing variants, a genetic predisposition score (GPS) was calculated.

The researchers found that each additional diabetes-risk allele in the GPS correlated with a 3 percent elevated risk of CVD (odds ratio [OR], 1.03; 95 percent confidence interval, 1.00 to 1.06). By comparing extreme quartiles of the GPS, the OR was 1.47 for CVD risk (P for trend = 0.01). There was a significant positive association for GPS with hemoglobin A1c levels.

"In conclusion, we found that the genetic predisposition to T2D was significantly associated with an increased risk of CVD in patients with T2D," the authors write. "Further studies are needed to examine the relationship among the to T2D, glycemic control, and CVD."

Explore further: Poor health-related function, diabetes combo ups death risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Poor health-related function, diabetes combo ups death risk

March 30, 2012
(HealthDay) -- The combination of type 2 diabetes and impaired health-related functioning (HRF) is associated with an increased risk of cardiovascular disease (CVD) mortality, according to a study published online March 23 ...

NAFLD independently linked to cardiovascular disease

June 7, 2012
(HealthDay) -- Nonalcoholic fatty liver disease (NAFLD) is independently associated with an increased risk of cardiovascular disease (CVD), but it is not associated with a statistically significantly increased risk of cardiovascular ...

Variety of fruits, vegetables linked to lower diabetes risk

April 9, 2012
(HealthDay) -- Eating a greater quantity of vegetables and a greater variety of fruits and vegetables (F&V) correlates with a reduced risk of type 2 diabetes (T2D), according to a study published online April 3 in Diabetes ...

Genetic risks for type 2 diabetes span multiple ethnicities

February 9, 2012
A recent large and comprehensive analysis of 50,000 genetic variants across 2,000 genes linked to cardiovascular and metabolic function has identified four genes associated with type 2 diabetes (T2D) and six independent disease-associated ...

Diabetes associated with higher risk of cardiovascular problems in men

March 25, 2012
According to a new study by researchers at Brigham and Women's Hospital (BWH), men with type 2 diabetes treated with insulin without a history of cardiovascular disease (CVD) were at higher risk for major cardiovascular events ...

Resting heart rate predicts overall, cardiovascular mortality

August 21, 2012
(HealthDay) -- High resting heart rates seem to be predictive of increased risk for overall and cardiovascular disease (CVD) mortality and shorter survival times, according to a study published in the Aug. 15 issue of The ...

Recommended for you

Laser device placed on the heart identifies insufficient oxygenation better than other measures

September 20, 2017
A new device can assess in real time whether the body's tissues are receiving enough oxygen and, placed on the heart, can predict cardiac arrest in critically ill heart patients, report researchers at Boston Children's Hospital ...

Metabolism switch signals end for healing hearts

September 19, 2017
Researchers have identified the process that shuts down the human heart's ability to heal itself, and are now searching for a drug to reverse it.

Beta blockers not needed after heart attack if other medications taken

September 18, 2017
A new study from the University of North Carolina at Chapel Hill finds beta blockers are not needed after a heart attack if heart-attack survivors are taking ACE inhibitors and statins. The study is the first to challenge ...

Which single behavior best prevents high blood pressure?

September 15, 2017
(HealthDay)—You probably already know that certain healthy lifestyle behaviors can reduce your risk of developing high blood pressure, but is any one behavior more important than the others?

RESPECT trial shows closing a small hole in heart may protect against recurrent stroke

September 13, 2017
A device used to close a small hole in the heart may benefit certain stroke patients by providing an extra layer of protection for those facing years of ongoing stroke risk, according to the results of a large clinical trial ...

Study shows so-called 'healthy obesity' is harmful to cardiovascular health

September 11, 2017
Clinicians are being warned not to ignore the increased cardiovascular health risks of those who are classed as either 'healthy obese' or deemed to be 'normal weight' but have metabolic abnormalities such as diabetes.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.