Larger study confirms statins' role in preventing cardiac events

October 5, 2012
Larger study confirms statins' role in preventing cardiac events
A large and unselected community-based study has confirmed the results of randomized controlled trials that have found persistent statin use to be beneficial for the primary prevention of acute cardiac events; the study was published online Sept. 27 in The American Journal of Cardiology.

(HealthDay)—A large and unselected community-based study has confirmed the results of randomized controlled trials that have found persistent statin use to be beneficial for the primary prevention of acute cardiac events; the study was published online Sept. 27 in The American Journal of Cardiology.

Varda Shalev, M.D., from Tel Aviv University in Israel, and colleagues examined the effectiveness of in primary prevention of acute nonfatal in the community setting. Data were analyzed from a cohort of 171,535 adults aged 45 to 75 years, without cardiovascular disease, who were given statins between 1998 to 2009 in a large health maintenance organization in Israel.

The researchers found that the incidence of acute cardiovascular events during the 993,519 person-years of follow-up was 10.22 per 1,000 person-years. Persistence with statins correlated with significantly reduced risk of incident cardiac events. There was a hazard ratio of 0.58 for the most persistent users (covered with statins for 80 percent or more of their follow-up time) compared with non-persistent users (less than 20 percent of days covered). When the analyses were limited to patients with more than five years of follow-up, the results were similar. Treatment with high efficacy statins correlated with a reduced risk of cardiac events.

"In conclusion, our large and unselected community-based study supports the results of regarding the beneficial effect of statins in the primary prevention of acute cardiac events," the authors write.

Explore further: Statins appear associated with reduced risk of recurrent cardiovascular events in men, women

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Statins appear associated with reduced risk of recurrent cardiovascular events in men, women

June 25, 2012
Cholesterol-lowering statin drugs appear to be associated with reduced risk of recurrent cardiovascular events in men and women, but do not appear to be associated with reduced all-cause mortality or stroke in women, according ...

Statins are unlikely to prevent blood clots, analysis finds

September 18, 2012
Despite previous studies suggesting the contrary, statins (cholesterol-lowering drugs) may not prevent blood clots (venous thrombo-embolism) in adults, according to a large analysis by international researchers published ...

Non-HDL-C level associated with risk of major cardiovascular events among patients taking statins

March 27, 2012
Levels of non-high-density lipoprotein cholesterol (non-HDL-C) among statin-treated patients appears to be associated with the risk of developing a major cardiovascular event, such as a heart attack or stroke, as are levels ...

Cardiovascular risk counseling improves statin adherence

May 31, 2012
(HealthDay) -- For patients taking statins for prevention of cardiovascular disease (CVD), extended care with nurse-led cardiovascular risk-factor counseling improves statin adherence and reduces anxiety, with improvements ...

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

2 comments

Adjust slider to filter visible comments by rank

Display comments: newest first

alfie_null
not rated yet Oct 06, 2012
Since it wasn't mentioned, should I assume the authors have never had any relation with pharma that manufactures statins?
Doug_Huffman
not rated yet Oct 06, 2012
=Null, it'll cost YOU US$32 to find out. Journal format requires conflict of interest notice in the full text. Never ass-u-me anything.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.