Statin use is associated with a lower risk for incident stroke and transient ischemic attack (TIA) in a duration-dependent manner among patients with atrial fibrillation (AF), according to a study presented at the annual ...
May 15, 2023
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Using new genetic tools to study statins in human cells and mice, Stanford Medicine researchers and collaborators have uncovered how the cholesterol-lowering drugs protect the cells that line blood vessels.
May 11, 2023
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We've all recently gotten a crash-course in drug repurposing, thanks to near-daily news reports about efforts to identify existing medicines that could help treat COVID-19 in the early phase of the pandemic. A team of scientists ...
May 9, 2023
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Cardiovascular disease—the thickening and hardening of arteries causing increased risk of strokes and heart attacks—is the No. 1 cause of death worldwide, according to the World Health Organization. High cholesterol is ...
Apr 27, 2023
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A region-wide study in more than 50,000 patients with atrial fibrillation has found reduced risks of stroke and transient ischemic attack in those who started statins within a year of diagnosis compared with those who did ...
Apr 17, 2023
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Statin therapy does not exacerbate muscle injury, pain or fatigue in people engaging in moderate-intensity exercise, such as walking, according to a study published today in the Journal of the American College of Cardiology. ...
Apr 3, 2023
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Statin use is low for primary prevention of atherosclerotic cardiovascular disease (ASCVD), with the lowest use seen among Black and Hispanic adults, according to a study published online March 22 in JAMA Cardiology.
Mar 23, 2023
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Statins are the most commonly used medication in lowering blood cholesterol, prescribed to tens of millions in the Western world. Statins act through inhibition of the enzyme HMG CoA reductase. Nearly 20% of statin users ...
Mar 21, 2023
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A new study by Columbia University researchers suggests that cholesterol-lowering drugs called statins have the potential to reduce heart disease in people with obstructive sleep apnea, regardless of the use of CPAP machines ...
Mar 13, 2023
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People with HIV have impaired immune responses to some pathogens and immunizations, and during the COVID-19 pandemic, they often experienced severe symptoms if infected with SARS‐CoV‐2. New research led by investigators ...
Mar 9, 2023
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The statins (or HMG-CoA reductase inhibitors) are a class of drugs that lower cholesterol levels in people with or at risk of cardiovascular disease.
They lower cholesterol by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis. Inhibition of this enzyme in the liver results in decreased cholesterol synthesis as well as increased synthesis of LDL receptors, resulting in an increased clearance of low-density lipoprotein (LDL) from the bloodstream. The first results can be seen after one week of use and the effect is maximal after four to six weeks.
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