Diseases, Conditions, Syndromes

Coronary heart disease risk higher with COPD

Patients with chronic obstructive pulmonary disease (COPD) are more likely to have coronary heart disease (CHD), but no specific phenotypes have a higher risk, according to a study published online April 27 in PLOS ONE.

Cardiology

Lower statin threshold shown to be cost-effective

Expanding prescription of statin medication to reduce low-density lipoprotein cholesterol could be a cost-effective intervention against cardiovascular disease, according to a Northwestern Medicine study published in the ...

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Statin

The statins (or HMG-CoA reductase inhibitors) are a class of drugs that lower cholesterol levels in people with or at risk of cardiovascular disease.

They lower cholesterol by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis. Inhibition of this enzyme in the liver results in decreased cholesterol synthesis as well as increased synthesis of LDL receptors, resulting in an increased clearance of low-density lipoprotein (LDL) from the bloodstream. The first results can be seen after one week of use and the effect is maximal after four to six weeks.

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