Sphere-templated tissue scaffold is a viable subcutaneous implant

October 14, 2012
Sphere-templated tissue scaffold is a viable subcutaneous implant
Compared with high-density porous polyethylene implant materials, sphere-templated poly (2-hydroxyethyl methacrylate) tissue scaffold stimulates a minimal inflammatory response; supports cellular ingrowth, collagen formation, and neovascularization; and may induce less scar formation, according to an experimental study published online Oct. 8 in the Archives of Facial Plastic Surgery.

(HealthDay)—Compared with high-density porous polyethylene (HDPPE) implant materials, sphere-templated poly (2-hydroxyethyl methacrylate) (poly[HEMA]) tissue scaffold stimulates a minimal inflammatory response; supports cellular ingrowth, collagen formation, and neovascularization; and may induce less scar formation, according to an experimental study published online Oct. 8 in the Archives of Facial Plastic Surgery.

Amit D. Bhrany, M.D., of the University of Washington in Seattle, and colleagues conducted a study involving the subcutaneous implantation of poly(HEMA) and HDPPE disks into the dorsal subcutis of C57BL/6 mice to evaluate their use as .

The researchers found that poly(HEMA) and HDPPE implants resisted extrusion, elicited a minimal inflammatory response, and supported neovascularization. While cellular and collagen ingrowth occurred in both implants, collagen ingrowth was thicker in the HDPPE implant due to the larger porous structure, while poly(HEMA) had much thinner within smaller pores. Within the fibrous ingrowth of the HDPPE and individuals pores of poly(HEMA), blood vessels were observed.

"In conclusion, this study serves as a foundation demonstrating that, as a subcutaneous implant, the sphere-template poly(HEMA) tissue scaffold exhibits good biocompatibility and supports cellular infiltration, collagen formation, and neovascularization," the authors write. "Because of its tightly controlled porous structure, the sphere-templated poly(HEMA) implant also may induce less scar-type healing response than the HDPPE implant."

One author disclosed to Healionics, which has licensed the sphere-templated scaffold technology from the University of Washington.

Explore further: Keep smiling: Collagen matrix promotes gum healing around exposed roots

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Keep smiling: Collagen matrix promotes gum healing around exposed roots

March 4, 2012
Receding gums often result in tooth sensitivity and can lead to decay of the root and persistent inflammation of the gum. New research published in BioMed Central's open access journal Head & Face Medicine demonstrates that ...

New technology gives implants a protective covering

January 30, 2012
A technology developed by labseed, an EPFL spin-off, could prevent most breast implant rejections. The final product should be commercially available  as early as 2013.

Cosmetic surgery unaffected by French implant scare: study

January 27, 2012
Cosmetic surgery is booming worldwide and unaffected by the health scare prompted by a French breast implant company that used substandard silicone, a global body of plastic surgeons said Friday.

New research suggests PIP implant failures significantly higher than previously thought

April 17, 2012
New research published in the Journal of Plastic, Reconstructive and Aesthetic Surgery suggests that the failure rate of silicone breast implants manufactured by Poly Implant Prosthèse (PIP) could be as high as 33.8%.

Recommended for you

Children best placed to explain facts of surgery to patients, say experts

December 13, 2017
Getting children to design patient information leaflets may improve patient understanding before they have surgery, finds an article in the Christmas issue of The BMJ.

Drug may help surgical patients stop opioids sooner

December 13, 2017
(HealthDay)—Opioid painkillers after surgery can be the first step toward addiction for some patients. But a common drug might cut the amount of narcotics that patients need, a new study finds.

Burn victim saved by skin grafts from identical twin (Update)

November 23, 2017
A man doomed to die after suffering burns across 95 percent of his body was saved by skin transplants from his identical twin in a world-first operation, French doctors said Thursday.

Is a common shoulder surgery useless?

November 21, 2017
(HealthDay)—New research casts doubt on the true effectiveness of a common type of surgery used to ease shoulder pain.

Study shows electric bandages can fight biofilm infection, antimicrobial resistance

November 6, 2017
Researchers at The Ohio State University Wexner Medical Center have shown - for the first time - that special bandages using weak electric fields to disrupt bacterial biofilm infection can prevent infections, combat antibiotic ...

Obesity increases incidence, severity, costs of knee dislocations

November 3, 2017
A new study of more than 19,000 knee dislocation cases in the U.S. between 2000 and 2012 provides a painful indication of how the nation's obesity epidemic is changing the risk, severity and cost of a traumatic injury.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.