Tadalafil effective, safe in complete erectile dysfunction

October 14, 2012
Tadalafil effective, safe in complete erectile dysfunction
In men with complete erectile dysfunction, tadalafil 2.5 and 5 mg once-daily result an in intercourse success rate of 32.4 and 46.4 percent, respectively, according to research published online Oct. 4 in The Journal of Sexual Medicine.

(HealthDay)—In men with complete erectile dysfunction (ED), tadalafil 2.5 and 5 mg once-daily result an in intercourse success rate of 32.4 and 46.4 percent, respectively, according to research published online Oct. 4 in The Journal of Sexual Medicine.

Ridwan Shabsigh, M.D., of the Maimonides Medical Center in New York City, and colleagues conducted a post-hoc, pooled analysis of results from four randomized, double-blind trials evaluating the effects of tadalafil 2.5 or 5 mg compared with placebo in men with complete ED (no successful intercourse attempts at baseline).

After 12 weeks of once-daily treatment with tadalafil, the researchers found that the mean per-patient Profile question 3 (SEP3) increased from 0 percent to 32.4 and 46.4 percent with 2.5 and 5 mg tadalafil, respectively. The SEP2 (successful penetration) increased from 21.1 to 48.2 percent and 24.4 to 66.2 percent with 2.5 and 5 mg tadalafil, respectively. The mean International Index of Erectile Function increased significantly with 2.5 and 5 mg tadalafil versus placebo. Compared with placebo, improvements were also noted in intercourse-satisfaction and overall-satisfaction domains. Tadalafil was well tolerated with no increase in versus placebo.

"Once-daily tadalafil 2.5 or 5 mg significantly enhanced erectile function (versus placebo) across all coprimary and secondary efficacy end points in this analysis, and was generally well tolerated," the authors write.

The four base studies and the reported analysis were sponsored by ; several authors disclosed to pharmaceutical companies, including Eli Lilly, which manufactures tadalafil.

Explore further: Donepezil found helpful in dementia with lewy bodies

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Donepezil found helpful in dementia with lewy bodies

July 31, 2012
(HealthDay) -- For patients with dementia with Lewy bodies (DLB), treatment with 5 or 10 mg/day donepezil is associated with significant cognitive, behavioral, and global function improvements, according to research published ...

Sumatriptan/Naproxen helpful in treating teens' migraines

May 15, 2012
(HealthDay) -- Treatment with sumatriptan and naproxen sodium (suma/nap) is well tolerated and effective in reducing migraine pain in adolescents, according to a study published online May 14 in Pediatrics.

ECO: New weight loss drug effective in advanced obesity

May 14, 2012
(HealthDay) -- A new combination treatment of controlled-release phentermine/topiramate (PHEN/TPM CR) leads to significantly greater weight loss than a placebo even in individuals with significant obesity-related comorbidities, ...

Recommended for you

Pneumonia vaccine under development provides 'most comprehensive coverage' to date, alleviates antimicrobial concerns

October 20, 2017
In 2004, pneumonia killed more than 2 million children worldwide, according to the World Health Organization. By 2015, the number was less than 1 million.

Newly discovered viral marker could help predict flu severity in infected patients

October 20, 2017
Flu viruses contain defective genetic material that may activate the immune system in infected patients, and new research published in PLOS Pathogens suggests that lower levels of these molecules could increase flu severity.

H7N9 influenza is both lethal and transmissible in animal model for flu

October 19, 2017
In 2013, an influenza virus that had never before been detected began circulating among poultry in China. It caused several waves of human infection and in late 2016, the number of people to become sick from the H7N9 virus ...

Flu simulations suggest pandemics more likely in spring, early summer

October 19, 2017
New statistical simulations suggest that Northern Hemisphere flu pandemics are most likely to emerge in late spring or early summer at the tail end of the normal flu season, according to a new study published in PLOS Computational ...

New insights into herpes virus could inform vaccine development

October 18, 2017
A team of scientists has discovered new insights into the mechanisms of Epstein-Barr virus (EBV) infection, as well as two antibodies that block the virus' entry into cells. The findings, published in Proceedings of the National ...

Pair of discoveries illuminate new paths to flu and anthrax treatments

October 17, 2017
Two recent studies led by biologists at the University of California San Diego have set the research groundwork for new avenues to treat influenza and anthrax poisoning.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.