Single C-peptide as good as full mixed-meal tolerance test

November 2, 2012
Single C-peptide as good as full mixed-meal tolerance test
For children and adolescents with type 1 diabetes, the 90-minute mixed-meal tolerance test (MMTT)-stimulated C-peptide is a highly sensitive and specific measure of area under the curve and peak C-peptide and may be used as an alternative to a full MMTT, according to a study published online Oct. 30 in Diabetes Care.

(HealthDay)—For children and adolescents with type 1 diabetes, the 90-minute mixed-meal tolerance test (MMTT)-stimulated C-peptide (CP; 90CP) is a highly sensitive and specific measure of area under the curve (AUC) and peak CP and may be used as an alternative to a full MMTT, according to a study published online Oct. 30 in Diabetes Care.

Rachel E.J. Besser, Ph.D., from Peninsula Medical School at the University of Exeter in the United Kingdom, and colleagues examined whether 90CP or fasting CP (FCP) can be used as alternatives to a full MMTT. In 421 patients younger than 18 years with type 1 , CP was measured during 1,334 MMTTs at three, nine, 18, 48, and 72 months of diabetes duration.

The researchers found a correlation for AUC CP of 0.96 for 90CP and 0.84 for FCP. AUC CP ≥23 nmol/L/150 min was the equivalent cut-off for peak CP ≥0.2 nmol/L, with 98 percent sensitivity and 97 percent specificity. A 90CP ≥0.2 nmol/L correctly classified 96 percent of patients using AUC or peak CP, while an FCP ≥0.1 nmol/L correctly classified 83 and 85 percent of patients, respectively. Only a small difference was noted between peak and 90CP. Patients with longer duration of diabetes and younger age had an earlier occurring CP peak.

"In conclusion, our study demonstrates that, in children and with , a mixed-meal stimulated 90-min CP is a highly sensitive, specific, and practical alternative measure to peak and AUC CP, with advantages over FCP," the authors write.

Explore further: Chronic periodontitis increases risk of psoriasis

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Chronic periodontitis increases risk of psoriasis

July 19, 2012
(HealthDay) -- Patients with chronic periodontitis (CP) are 1.5 times more likely to be diagnosed with psoriasis, and this risk is lessened but not nullified by CP treatment using gingivectomy or periodontal flap operation, ...

Early loss of glucagon response to hypoglycemia found in teens

June 22, 2012
(HealthDay) -- In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 ...

Recommended for you

Personalized blood sugar goals can save diabetes patients thousands

December 11, 2017
A cost analysis by researchers at the University of Chicago Medicine shows treatment plans that set individualized blood sugar goals for diabetes patients, tailored to their age and health history, can save $13,546 in health ...

Kidney disease increases risk of diabetes, study shows

December 11, 2017
Diabetes is known to increase a person's risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of ...

Type 2 diabetes is not for life

December 5, 2017
Almost half of the patients with Type 2 diabetes supported by their GPs on a weight loss programme were able to reverse their diabetes in a year, a study has found.

Skipping breakfast disrupts 'clock genes' that regulate body weight

November 30, 2017
Irregular eating habits such as skipping breakfast are often associated with obesity, type 2 diabetes, hypertension and cardiovascular disease, but the precise impact of meal times on the body's internal clock has been less ...

Type 2 diabetes has hepatic origins

November 28, 2017
Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type ...

Critical link between obesity and diabetes has been identified

November 28, 2017
UT Southwestern researchers have identified a major mechanism by which obesity causes type 2 diabetes, which is a common complication of being overweight that afflicts more than 30 million Americans and over 400 million ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.