Early loss of glucagon response to hypoglycemia found in teens

June 22, 2012
Early loss of glucagon response to hypoglycemia found in teens
In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 in Diabetes Care.

(HealthDay) -- In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 in Diabetes Care.

To investigate the glucagon response to hypoglycemia in adolescents with type 1 diabetes, Aris Siafarikas, M.D., of the Princess Margaret Hospital for Children in Perth, Australia, and colleagues conducted a study involving 28 nonobese adolescents with type 1 diabetes (median duration, 0.66 years) and 12 healthy control subjects.

The researchers found that there was a similar glucagon peak to arginine stimulation between the groups (P = 0.27). In adolescents with type 1 diabetes the glucagon peak to hypoglycemia was statistically significantly lower than in control individuals (68 versus 96 pg/mL). For 7 percent of adolescents with diabetes and 83 percent of controls this response was more than three standard deviations greater from baseline and was lost after a median duration of eight months of diabetes and as early as one month after diagnosis. The response did not correlate with height, weight, , or glycated hemoglobin.

"We conclude that adolescents with type 1 diabetes have impaired glucagon responses to hypoglycemia within 12 months of diagnosis," the authors write. "Prospective studies in children and adolescents starting from the onset of are needed to further characterize the mechanisms influencing the change over time in the response to hypoglycemia."

Explore further: Diet soda linked to increase in glucagon-like peptide 1 levels

More information: Abstract
Full Text (subscription or payment may be required)


Related Stories

Diet soda linked to increase in glucagon-like peptide 1 levels

March 22, 2012
(HealthDay) -- Drinking a diet soda before a glucose load is associated with increased glucagon-like peptide 1 (GLP-1) secretion in individuals with type 1 diabetes and healthy controls, but not in those with type 2 diabetes, ...

Liquid glucagon formulation discovered for potential use in artificial pancreas systems

June 12, 2012
Researchers at Oregon Health & Science University (OHSU) and Legacy Health have discovered a liquid glucagon formulation that may be useable in standard diabetes pumps. Such a formulation could broaden the use of glucagon ...

Heart rate affected by nocturnal hypoglycemia in T1DM patients

June 1, 2012
(HealthDay) -- For adults with type 1 diabetes there is a marked decrease in the low-frequency component of heart rate variability during spontaneous nocturnal hypoglycemia, according to a study published online May 18 in ...

New inflammation hormone link may pave way to study new drugs for Type 2 diabetes

May 15, 2012
A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found.

Study assesses glucose monitoring trends in tweens

April 12, 2012
(HealthDay) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April ...

Recommended for you

Diabetes pill might replace injection to control blood sugar

October 17, 2017
(HealthDay)— An injectable class of diabetes medication—called glucagon-like peptide-1 or GLP-1—might one day be available in pill form, research suggests.

Skimping on sleep may contribute to gestational diabetes

October 17, 2017
The amount of time spent sleeping in the United States has dropped significantly in the past twenty years with almost a quarter of women and 16 percent of men experiencing insufficient sleep. Now, a new study has found that ...

Artificial pancreas performs well in clinical trial

October 16, 2017
During more than 60,000 hours of combined use of a novel artificial pancreas system, participants in a 12-week, multi-site clinical trial showed significant improvements in two key measures of well-being in people living ...

Omega-6 fats may help prevent type 2 diabetes

October 11, 2017
The risk of developing type 2 diabetes could be significantly reduced by eating a diet rich in omega-6 polyunsaturated fats, a new study suggests.

Where there's type 1 diabetes, celiac disease may follow

October 10, 2017
(HealthDay)—Parents of young children with type 1 diabetes need to be on the lookout for symptoms of another autoimmune condition—celiac disease, new research suggests.

Type 1 diabetes and the microbiota—MAIT cells as biomarkers and new therapeutic targets

October 10, 2017
Together with colleagues from AP-HP Necker–Enfants Malades Hospital in Paris, scientists from the Cochin Institute (CNRS / INSERM / Paris Descartes University) have discovered that the onset of type 1 diabetes is preceded ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.