Fenofibrate / simvastatin benefit in dyslipidemia explored

November 1, 2012
Fenofibrate/Simvastatin benefit in dyslipidemia explored
Combination treatment with fenofibrate and simvastatin significantly reduces postprandial triglyceride levels compared with simvastatin alone in all subjects, regardless of fasting triglyceride level, but reduces atherogenic apolipoprotein B48 particles only in those with increased fasting triglyceride levels, according to research published online Oct. 25 in Diabetes Care.

(HealthDay)—Combination treatment with fenofibrate and simvastatin (FENO-S) significantly reduces postprandial (PP) triglyceride (TG) levels compared with simvastatin alone in all subjects, regardless of fasting TG level, but reduces atherogenic apolipoprotein (apo) B48 particles only in those with increased fasting TG levels, according to research published online Oct. 25 in Diabetes Care.

Gissette Reyes-Soffer, M.D., of the Columbia University Medical Center in New York City, and colleagues conducted a study involving a subset of 139 subjects (mean age, 61 years) from the Action to Control in Diabetes lipid study (ACCORD Lipid) to evaluate the effect of combination therapy with FENO-S compared with placebo plus (PL-S) on PP lipid and lipoprotein levels. Primary measures included PP plasma TG, apoB48, and apoCIII, measured over 10 hours after an oral fat load.

The researchers found that the PP TG incremental area under the curve (IAUC) above fasting was 572 and 770 in the FENO-S and PL-S groups, respectively (P = 0.008). In the FENO-S versus the PL-S group, there was a significant reduction in PP apoB48 IAUC. On the day of the study, fasting TG levels correlated with PP TG IAUC for both FENO-S and PL-S groups. For PP TG IAUC, the fibrate effect was constant across the range of fasting TG levels, while for PP apoB48 IAUC, the reduction was only seen when fasting TG levels were increased.

"These results may have implications for interpretation of the overall ACCORD Lipid trial, which suggested benefit from FENO-S only in dyslipidemic individuals," the authors write.

One author disclosed to and Merck Pharmaceuticals, both of which provided the study medications for the ACCORD Lipid trial.

Explore further: The Homburg Cream and Sugar study

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

The Homburg Cream and Sugar study

August 29, 2011
The Homburg Cream and Sugar (HCS) study was designed to determine whether the measurement of postprandial triglyceride in addition to the assessment of glucose tolerance and traditional risk factors might improve the prediction ...

Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome

April 5, 2012
In most people, high blood levels of the fat known as triglycerides are an early warning sign of type 2 diabetes and metabolic syndrome, but in people of African descent these dangerous health conditions may go undiagnosed ...

Recommended for you

Scientists reverse diabetes in a mouse model using modified blood stem cells

November 15, 2017
Researchers at Boston Children's Hospital have successfully reversed type 1 diabetes in a mouse model by infusing blood stem cells pre-treated to produce more of a protein called PD-L1, which is deficient in mice (and people) ...

Pregnancy-related conditions taken together leave moms—and dads—at risk

November 14, 2017
Research has already shown that women who develop either diabetes or high blood pressure during pregnancy are at risk of getting type 2 diabetes, high blood pressure or heart disease years later. Now, a new study from a team ...

Study reveals how a very low calorie diet can reverse type 2 diabetes

November 9, 2017
In a new study, a Yale-led research team uncovers how a very low calorie diet can rapidly reverse type 2 diabetes in animal models. If confirmed in people, the insight provides potential new drug targets for treating this ...

Targeting a microRNA shows potential to enhance effectiveness of diabetes drugs

November 7, 2017
Over the past 15 years, University of Alabama at Birmingham endocrinologist Anath Shalev, M.D., has unraveled a crucial biological pathway that malfunctions in diabetes.

Researchers link Western diet to vascular damage and prediabetes

October 31, 2017
Could short-term exposure to the average American diet increase one's risk for developing diabetes and cardiovascular disease? According to a recent study funded by the American Heart Association (AHA), researchers from New ...

Researchers design synthetic beta cells to secrete insulin in response to high blood sugar

October 30, 2017
Treating type 1 diabetes and some cases of type 2 diabetes has long required painful and frequent insulin injections or a mechanical insulin pump for insulin infusion. But researchers from the University of North Carolina ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.