Study shows COPD is not independent risk factor for lung cancer

December 15, 2012

Chronic obstructive pulmonary disease (COPD) and lung cancer are two of the most important smoking-related diseases worldwide, with a huge combined mortality bur¬den. Many consider the presence of COPD itself to be an independent risk factor for lung cancer. Others argue that smoking contributes to both COPD and lung cancer. A recent study published in the January 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes that COPD is not an independent risk factor for lung cancer.

Researchers from the University of Nottingham looked at patients with lung cancer between January 2000 and July 2009 from The Health Improvement Network, a general practice database, in the United Kingdom.

Researchers, "found evidence of a strong association between COPD and lung cancer, but this was largely explained by the effect of smoking and is most apparent in recently diagnosed cases of COPD, suggesting a strong element of ascertainment bias."

They go on to say that there is "an extremely strong unadjusted relationship between both COPD and pneu¬monia and lung cancer in the 6 months immediately before lung cancer diagnosis. This is useful in a clinical context, high¬lighting the need to consider a diagnosis of lung cancer when making new diagnoses of COPD or pneumonia."

The researchers support the current recommendations of the and the U.K. National Institute for Health Research, that all patients should have a chest radiograph looking for evi¬dence of lung cancer at the time of COPD diagnosis.

The lead author of this work is Dr. Helen Powell. Co-authors include IASLC member Dr. David Baldwin.

Explore further: Early COPD detection could help lung cancer diagnosis

Related Stories

Early COPD detection could help lung cancer diagnosis

November 16, 2011
Early screening of patients with chronic obstructive pulmonary disease (COPD) may help to detect lung cancer at an earlier stage, according to a new study.

SBRT provides better outcomes than surgery for cancer patients with common lung disease

February 16, 2012
Stereotactic body radiotherapy (SBRT) provides better overall survival rates than surgery for lung cancer patients with severe chronic obstructive pulmonary disease (COPD), a disease commonly associated with lung cancer, ...

Latest research confirms genetic susceptibility to lung cancer

April 15, 2012
Previous research has shown that Asian patients with lung cancer are more likely to harbor epidermal growth factor receptor (EGFR) mutations. Furthermore, Asian patients with lung cancer are more likely to be non-smokers ...

Sniffer dogs can be used to detect lung cancer

August 18, 2011
Sniffer dogs could be used for the early detection of lung cancer, according to new research published in the European Respiratory Journal.

How chronic obstructive pulmonary disease increases risk of lung cancer

July 24, 2012
In addition to the well-known risk factor of smoking, chronic obstructive pulmonary disease (COPD) increases lung cancer risk.

Roflumilast improves lung function after 6 months compared with placebo

October 22, 2012
Roflumilast was associated with significant improvements in lung function in patients with moderate and severe chronic obstructive pulmonary disease (COPD) after 6 months of treatment compared with placebo.

Recommended for you

Vitamin C may encourage blood cancer stem cells to die

August 17, 2017
Vitamin C may "tell" faulty stem cells in the bone marrow to mature and die normally, instead of multiplying to cause blood cancers. This is the finding of a study led by researchers from Perlmutter Cancer Center at NYU Langone ...

Outdoor light at night linked with increased breast cancer risk in women

August 17, 2017
Women who live in areas with higher levels of outdoor light at night may be at higher risk for breast cancer than those living in areas with lower levels, according to a large long-term study from Harvard T.H. Chan School ...

Scientists develop novel immunotherapy technology for prostate cancer

August 17, 2017
A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific ...

Toxic formaldehyde is produced inside our own cells, scientists discover

August 16, 2017
New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment - it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing ...

Cell cycle-blocking drugs can shrink tumors by enlisting immune system in attack on cancer

August 16, 2017
In the brief time that drugs known as CDK4/6 inhibitors have been approved for the treatment of metastatic breast cancer, doctors have made a startling observation: in certain patients, the drugs—designed to halt cancer ...

Researchers find 'switch' that turns on immune cells' tumor-killing ability

August 16, 2017
Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.