Study shows COPD is not independent risk factor for lung cancer

December 15, 2012

Chronic obstructive pulmonary disease (COPD) and lung cancer are two of the most important smoking-related diseases worldwide, with a huge combined mortality bur¬den. Many consider the presence of COPD itself to be an independent risk factor for lung cancer. Others argue that smoking contributes to both COPD and lung cancer. A recent study published in the January 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes that COPD is not an independent risk factor for lung cancer.

Researchers from the University of Nottingham looked at patients with lung cancer between January 2000 and July 2009 from The Health Improvement Network, a general practice database, in the United Kingdom.

Researchers, "found evidence of a strong association between COPD and lung cancer, but this was largely explained by the effect of smoking and is most apparent in recently diagnosed cases of COPD, suggesting a strong element of ascertainment bias."

They go on to say that there is "an extremely strong unadjusted relationship between both COPD and pneu¬monia and lung cancer in the 6 months immediately before lung cancer diagnosis. This is useful in a clinical context, high¬lighting the need to consider a diagnosis of lung cancer when making new diagnoses of COPD or pneumonia."

The researchers support the current recommendations of the and the U.K. National Institute for Health Research, that all patients should have a chest radiograph looking for evi¬dence of lung cancer at the time of COPD diagnosis.

The lead author of this work is Dr. Helen Powell. Co-authors include IASLC member Dr. David Baldwin.

Explore further: Early COPD detection could help lung cancer diagnosis

Related Stories

Early COPD detection could help lung cancer diagnosis

November 16, 2011
Early screening of patients with chronic obstructive pulmonary disease (COPD) may help to detect lung cancer at an earlier stage, according to a new study.

SBRT provides better outcomes than surgery for cancer patients with common lung disease

February 16, 2012
Stereotactic body radiotherapy (SBRT) provides better overall survival rates than surgery for lung cancer patients with severe chronic obstructive pulmonary disease (COPD), a disease commonly associated with lung cancer, ...

Latest research confirms genetic susceptibility to lung cancer

April 15, 2012
Previous research has shown that Asian patients with lung cancer are more likely to harbor epidermal growth factor receptor (EGFR) mutations. Furthermore, Asian patients with lung cancer are more likely to be non-smokers ...

Sniffer dogs can be used to detect lung cancer

August 18, 2011
Sniffer dogs could be used for the early detection of lung cancer, according to new research published in the European Respiratory Journal.

How chronic obstructive pulmonary disease increases risk of lung cancer

July 24, 2012
In addition to the well-known risk factor of smoking, chronic obstructive pulmonary disease (COPD) increases lung cancer risk.

Roflumilast improves lung function after 6 months compared with placebo

October 22, 2012
Roflumilast was associated with significant improvements in lung function in patients with moderate and severe chronic obstructive pulmonary disease (COPD) after 6 months of treatment compared with placebo.

Recommended for you

Researchers release first draft of a genome-wide cancer 'dependency map'

July 27, 2017
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have identified more than 760 genes ...

Cancer-death button gets jammed by gut bacterium

July 27, 2017
Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy ...

Long-sought mechanism of metastasis is discovered in pancreatic cancer

July 27, 2017
Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power ...

Blocking the back-door that cancer cells use to escape death by radiotherapy

July 27, 2017
A natural healing mechanism of the body may be reducing the efficiency of radiotherapy in breast cancer patients, according to a new study.

Manmade peptides reduce breast cancer's spread

July 27, 2017
Manmade peptides that directly disrupt the inner workings of a gene known to support cancer's spread significantly reduce metastasis in a mouse model of breast cancer, scientists say.

Glowing tumor technology helps surgeons remove hidden cancer cells

July 27, 2017
Surgeons were able to identify and remove a greater number of cancerous nodules from lung cancer patients when combining intraoperative molecular imaging (IMI) - through the use of a contrast agent that makes tumor cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.