Extreme macrocephaly treated by shunting and cranial reduction/fixation in 1st week of life

December 11, 2012

Neurosurgeons at All Children's Hospital/Johns Hopkins Medicine (St. Petersburg, FL) and the University of South Florida Morsani College of Medicine (Tampa, FL) recently achieved excellent physical and aesthetic results in an infant born with extreme macrocephaly due to hydrocephalus. This was accomplished with routine implantation of a ventriculoperitoneal shunt followed by a new operation to stabilize and reduce the size of the baby's head. Both surgeries were performed during the infant's first week of life. The surgeons report that as far as they know, this is the first reported case of cranial fixation in such a young child with extreme hydrocephalus. Full details of the surgical procedures and their successful outcomes can be found in the article "Cranial reduction and fixation with a resorbable plate combined with cerebrospinal fluid shunting for difficult-to-manage macrocephaly related to hydrocephalus," by Jotham Manwaring, M.D., and colleagues, published today online, ahead of print, in the Journal of Neurosurgery: Pediatrics.

In this article the authors report the case of an infant born with extreme macrocephaly. The baby's head measured 50 cm in (more than the 99th percentile). His anterior fontanel bulged, and there was wide separation between the bones of all cranial sutures (see accompanying figure). confirmed the diagnosis of severe hydrocephalus.

When the infant was 2 days old, surgery was performed to implant a ventriculoperitoneal shunt with a programmable valve. The performance level of the valve was adjusted repeatedly over the next few days to balance drainage of cerebrospinal fluid (CSF). Despite multiple shunt valve adjustments, a satisfactory balance could not be achieved to allow sufficient CSF drainage without creating a dysmorphic skull appearance. This often occurs in infants with congenital hydrocephalus and markedly enlarged skulls. The surgeons decided to perform a cranial reduction and stabilization procedure in an effort to improve the child's appearance, to facilitate his care, and to allow adequate CSF drainage without resulting in skull bone overlap.

Gerald Tuite, M.D., and Devon Truong, P.A.-C, the developers of the procedure, together with their colleagues began the operation by creating an incision just behind the anterior fontanel. The surgical team drained enough CSF from the ventricles to bring both frontal and parietal bones together, resulting in a far better shape of the infant's head. The team placed a resorbable plate across the entire anterior fontanel and affixed the parietal and frontal bones firmly in place. This prevented the development of unsightly overlaps, which commonly occur when a skull is disproportionately large compared to the size of the underlying brain. The procedure took 45 minutes and the infant tolerated it well. Immediately postoperatively, the shape of the infant's head was much improved and it was much easier to care for him. There was no longer the need for frequent repositioning or shunt valve adjustments to try to regulate head shape. Not only were the cranial bones held solidly in place, but the cranial volume was reduced by approximately 49%.

Follow-up examinations showed that as the child became older, his cranial bones grew over the anterior fontanel to meet at the sutures and the implanted plate was absorbed by the body. At 17 months, the infant displayed near-normal development (with a slight motor delay) and required no medication or additional surgery. The shunt is still in place and functioning well. The infant's appearance remains excellent.

The importance of this paper is the timing of the cranial reduction and stabilization procedure. It was accomplished shortly after shunt implantation, within the first week of life—much earlier than reported in other papers. The authors state that this early intervention was much less technically challenging than later reconstructions, which sometimes require more than one surgical procedure, can carry more risks, and may not achieve the aesthetic outcome desired. In this case, only one 45-minute reconstructive surgery was required. The authors also suggest that further modifications of their procedure could make it simpler and even possibly include shunt implantation during the same surgery.

Using the technique described in this paper, the authors state, "Early shunting combined with a limited cranial reduction and fixation procedure facilitated patient positioning, simplified management of hydrocephalus, and provided an excellent aesthetic outcome in an infant with extreme macrocephaly related to hydrocephalus."

Explore further: Tablet computers may interfere with settings on magnetically programmable shunt valves

More information: Manwaring JC, Truong D, Deukmedjian AR, Carey CM, Storrs BB, Rodriguez LF, Tetreault L, Tuite GF. Cranial reduction and fixation with a resorbable plate combined with cerebrospinal fluid shunting for difficult-to-manage macrocephaly related to hydrocephalus. Journal of Neurosurgery: Pediatrics, published online, ahead of print, December 11, 2012; DOI: 10.3171/2012.10.PEDS12340

Related Stories

Tablet computers may interfere with settings on magnetically programmable shunt valves

June 26, 2012
Researchers at the University of Michigan have found that the Apple iPad 2 can interfere with settings of magnetically programmable shunt devices, which are often used to treat children with hydrocephalus. The iPad 2 contains ...

Recommended for you

New surgical strategy offers hope for repairing spinal injuries

July 28, 2017
Scientists in the UK and Sweden previously developed a new surgical technique to reconnect sensory neurons to the spinal cord after traumatic spinal injuries. Now, they have gained new insight into how the technique works ...

Scientists block evolution's molecular nerve pruning in rodents

July 27, 2017
Researchers investigating why some people suffer from motor disabilities report they may have dialed back evolution's clock a few ticks by blocking molecular pruning of sophisticated brain-to-limb nerve connections in maturing ...

In witnessing the brain's 'aha!' moment, scientists shed light on biology of consciousness

July 27, 2017
Columbia scientists have identified the brain's 'aha!' moment—that flash in time when you suddenly become aware of information, such as knowing the answer to a difficult question. Today's findings in humans, combined with ...

Social influences can override aggression in male mice, study shows

July 27, 2017
Stanford University School of Medicine investigators have identified a cluster of nerve cells in the male mouse's brain that, when activated, triggers territorial rage in a variety of situations. Activating the same cluster ...

Scientists become research subjects in after-hours brain-scanning project

July 27, 2017
A quest to analyze the unique features of individual human brains evolved into the so-called Midnight Scan Club, a group of scientists who had big ideas but almost no funding and little time to research the trillions of neural ...

Researchers reveal unusual chemistry of protein with role in neurodegenerative disorders

July 27, 2017
A common feature of neurodegenerative diseases is the formation of permanent tangles of insoluble proteins in cells. The beta-amyloid plaques found in people with Alzheimer's disease and the inclusion bodies in motor neurons ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.