Scientists link excess sugar to cancer

February 1, 2013, University Rey Juan Carlos
Scientists link excess sugar to cancer
Scientists link excess sugar to cancer.

Sugars are needed to provide us with energy and in moderate amounts contribute to our well-being. Sustained high levels of sugars, as is found in diabetics, damages our cells and now is shown that can also increase our chance to get cancer: The dose makes the poison as Paracelsus said.

It is well known that obesity is a leading cause of , a disease where the body fails to control . levels are characteristic in obesity and diabetes. What is less well known is that diabetes and obesity are also linked to an increase in risk. That is, the diabetic population has up to double chances to suffer pancreatic or among others, according to well sustained . With obesity in British and Spanish children reaching 16%, the highest in Europe, this epidemic has major . How obesity or diabetes increase cancer risk has been a major health issue.

Scientists led by Dr. Custodia Garcia-Jimenez at the University Rey Juan Carlos in Madrid have uncovered a key mechanism that links obesity and diabetes with cancer: high sugar levels, which increase activity of a gene widely implicated in cancer progression.

Dr Garcia Jimenez's laboratory was studying how cells in the intestine respond to sugars and signal to the pancreas to release insulin, the key hormone that controls blood sugar levels. Sugars in the intestine trigger cells to release a hormone called GIP that enhances by the pancreas.

In a study published in Molecular Cell, Dr Garcia Jimenez's team showed that the ability of the to secrete GIP is controlled by a protein called β-catenin, and that the activity of β-catenin is strictly dependent on sugar levels.

Increased activity of β-catenin is known to be a major factor in the development of many cancers and can make normal cells immortal, a key step in early stages of . The study demonstrates that high (but not normal) sugar levels induce nuclear accumulation of β-catenin and leads to cell proliferation. The changes induced on β-catenin, the molecules involved and the diversity of cancer cells susceptible to these changes are identified.

Dr. Custodia García said "We were surprised to realize that changes in our metabolism caused by dietary sugar impact on our cancer risk. We are now investigating what other dietary components may influence our cancer risk. Changing diet is one of easiest prevention strategies that can potentially save a lot of suffering and money".

Colin Goding, Professor of Oncology at the University of Oxford, UK said 'Previously we were unsure about how increased blood sugar found in diabetes and obesity could increase cancer risk. This study identifies a key molecular mechanism through which high blood glucose would predispose to cancer. It opens the way for potential novel therapies aimed at reducing in the obese and diabetic populations.'

Estimations published by the World Health Organisation (WHO): Obesity predisposes to diabetes and its prevalence is doubling every 20 years worldwide. More than 1 in 10 adults worldwide (12%) are obese (BMI>30). 1 in 6 children in UK and Spain suffer obesity.

Diabetes caused 4.6 million deaths in 2011, more than 2 deaths per hour in Spain, more in USA. Worldwide, 1 in 10 adults (10%) suffered from diabetes in 2010 and more than one-third of individuals with diabetes are unaware they suffer from the disease. The national cost of diabetes or cancer is in the order of billions of pounds or euros in Spain or England.

More than half (63%) of premature deaths worldwide are due to non communicable diseases (NCD) of which cancer and diabetes are among the 4 causes more frequent.

At least 1 in 3 of the main cancers (27–39%) can be prevented by improving diet, physical activity and body composition.

Explore further: Diabetic drug could help prevent the spread of cancer

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1.9 / 5 (9) Feb 01, 2013
Life should be linked to cancer.
2.8 / 5 (9) Feb 01, 2013
Cancer should be linked to conservatism
4 / 5 (5) Feb 01, 2013
Life should be linked to cancer.

It is.

Oxygen is a nasty, nasty poison. Using oxygen in your metabolism causes on the order of 50 000 DNA damages per _cell_ per day. Most of those are very quickly repaired. Most cells which do not manage to repair their DNA undergo apoptosis. Most of the cells which do not undergo apoptosis are cleaned up by the immune system. Most of the cells that aren't cleaned up by the immune system have a benign mutation. Of those that survive all this and have a mutation that is not benign, you get a ticking time bomb, which may or may not progress to cancer. Abnormal, precancerous cells compete for resources and reproduce without contact inhibition etc. in a way healthy cells do not. Through natural selection, the most malignant cells survive and accumulate more mutations until you get to something like a cancerous tumour.
2.7 / 5 (9) Feb 02, 2013
Exercise kills cancer. If you're currently under the treatment of a professional who is telling you to take it easy, you are not getting optimal care. Chemical and radiation therapies are very effective but proper nutrition and an exercise program in conjunction with these conventional therapies will maximize your recovery potential. If you are currently suffering or know of someone that is, investigate for yourself. There is much supporting evidence that exercise is not only an effective preventative measure but also a good therapeutic one.

There are many cases of people making full recoveries with exercise and nutrition alone (Without Any Medical Treatment!) I would personally recommend continuing medical treatment, and along with it, no matter how hard it seems, start exercising! Fight the cancer by strengthening your body so it can attack the cancer from within!
2.8 / 5 (9) Feb 02, 2013
There are many cases of people making full recoveries with exercise and nutrition alone (Without Any Medical Treatment!)

We used to have a neighbour who had stomach cancer that had spread elsewhere. Doctors told him there was nothing they could do for him. So he started watching his nutrition, exercising every day and eating a vegan diet etc. He ended up living a few months longer than they gave him, and lost a lot of weight, but he still ended up dying from the disease. Unfortunately, there's no silver bullet.
3 / 5 (6) Feb 02, 2013
There are optimistic assumptions in the issue of 'watching his nutrition' etc Just eating so called good food is not nearly enough, one must know what key minerals are present or deficient.

Cancerous cells are effectively immortal cells which ignore the signal for apoptosis and also they consume more energy than normal.

There is a credible theory cancerous cells arise daily yet are recognised by the immune system and destroyed however, a well functioning immune system should be rich in several key metals such as copper and zinc.

There are >200 enzymes that compete just for copper but dont necessarily do so with any equanimity. Most people on a western diet are well below the RDI for copper and molybdenum and many are also deficient to the degree it upsets immune system signalling.

Effective nutrition should include a good understanding of minerals and local growing conditions such that healthy levels of key minerals are actually present *and* in a form that are most bioavailable.
3 / 5 (6) Feb 02, 2013
Sorry to hear about your neighbor. Recovery success does rest on which stage the cancer has progressed to. A cancer which has spread throughout the whole body has a lower recovery probability than a cancer which has affected a smaller portion of the body. It seems that even at this late stage he managed to extend his life past what the doctors predicted. So I guess the lifestyle change still made a difference in his case.

Exercise does strengthen the immune system, so when interferons are released, white blood cells are there to spring into action.

This is why proper nutrition and exercise helps, healthy lifestyles increase the bodies capability to fight disease. Get active and properly nourish yourself to strengthen your immune system. If in the end you lose the battle, at least it will be as a warrior. Do not give up hope. Many have made it through on mental toughness alone. If you know that you will beat your disease, you will. The placebo effect is very much real.
1.8 / 5 (5) Feb 02, 2013
Kron was a bit vague with
Exercise does strengthen the immune system, so when interferons are released, white blood cells are there to spring into action.
Surely predicated upon homeostasis of essential minerals ?

Eg. Sizable amounts of copper & zinc to ensure adequate & good levels of:- http://en.wikiped...ismutase
& effective levels of Cu transport protein which is a powerful anti-oxidant:- http://en.wikiped...oplasmin

Some cancers linked to bacterial & viral infections, take note all bacteria love iron & especially so when not metabolised correctly by low levels of enzyme Ferroxidase, which is copper based !

Biochemical logic is clear, healthy level of copper leads to sufficient Ferroxidase so iron (whether in food or supplements) are metabolised & not absorbed by pathogens (bad bacteria) which may instead cause toxin damage through equilibrium changes, such as the importance of (1.5Kg) bowels as bifido (good) digestion machinery, Cheers.
1 / 5 (2) Feb 02, 2013
"Just eating so called good food is not nearly enough, one must know what key minerals are present or deficient... A well functioning immune system should be rich in several key metals such as copper and zinc."
You need to maintain the daily calorie balance (it should be zero at the end of the day), and to get the required amounts of nutrients.
I've been using for calculating majority of norms (vitamins, minerals).
Requires IQ higher than the average, unfortunately.
1.8 / 5 (5) Feb 02, 2013
droid001 mumbled with considerable lack of scientific precision
...copper and zinc."
You need to maintain the daily calorie balance (it should be zero at the end of the day), and to get the required amounts of nutrients.
Pray tell how calories are related to minerals ? *&* how do you deal with the predisposition that the vast majority of market gardeners & other suppliers of staple vegetables do not fortify their soils (or hydroponics) with sufficient levels of zinc, copper,molybdenum, magnesium, manganese etc ?

I really would like to know, otherwise it appears as if your post is a spam to progress a website you may have some commercial interest in.

Where is there an Atomic Absorption Spectrometry (AAS) of the absolute levels of the key minerals & if I dont hear from you within seven (7) days I will have to conclude you have no idea what you are talking about re levels in mg/Kg of any of the fruits & vegetables of consequence in your calorific assessment...

3 / 5 (5) Feb 03, 2013
Gee, they rediscovered the Warburg effect from 90 years ago. They rediscover or investigate this every 10 to 15 years. Cancer cells acquire their energy from sugar rather than oxygen like normal cells. So the secret is to deprive the cancers cells of sugar which will encourage apoptosis.
This is what I did to recover from stage 4 cancer with 3-4 months to live. I immediately stopped my three times a week workout at 24 hour fitness. I avoided sugar intake and red meats. In addition to chemotherapy and radiation, I took the following types of supplements: anti-inflamatories, COX-2 inhibitors, chemotherapy enhancers, oxygen delivery enhancers, apoptosis stimulators, cell penetrators that repair DNA, certain anti-oxidants. All foods did not taste good except French fries and milkshakes. I lost 28% of my weight. When I got my appetite back, I knew I was cured and I gained all my weight back. (darn it.) Chemotherapy did not stop until I got my weight back.
2 / 5 (4) Feb 04, 2013
Congratulations to XQZME, in your particular case for the effort and survival but could he clarify
Cancer cells acquire their energy from sugar rather than oxygen like normal cells. So the secret is to deprive the cancers cells of sugar which will encourage apoptosis.
There is a causal flaw here, are you also rewriting all cell metabolism ???

Cells dont get energy from O2, it allows them to use glucose (from sucrose) thats where they get their base energy !

Cancers respire with oxygen just like normal cells, are you claiming fermentation ?

In terms of causation, there are many people who have been cured of cancer by a significant change of circumstances and I have personal experience of friends who have:-

- Ingested a mix of minerals and precious metals
- Dramatically increased exercise
- Large qty of Chinese herbal medicines

What seems to happen is "A significant change in bodily chemistry triggers the otherwise dumbed immune system to destroy cancer cells"

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