CMV-linked eye infections ID'd in patients without HIV

March 18, 2013
CMV-linked eye infections ID'd in patients without HIV
Cytomegalovirus-associated posterior uveitis or panuveitis can develop in patients without HIV infection, most of whom have evidence of compromised immune function, according to a study published online March 14 in JAMA Ophthalmology.

(HealthDay)—Cytomegalovirus (CMV)-associated posterior uveitis or panuveitis can develop in patients without HIV infection, most of whom have evidence of compromised immune function, according to a study published online March 14 in JAMA Ophthalmology.

Kessara Pathanapitoon, M.D., Ph.D., from Chiang Mai University in Thailand, and colleagues conducted a retrospective observational study to describe the clinical manifestations and comorbidities of 18 patients (22 eyes) without who have CMV-associated posterior uveitis or panuveitis.

The researchers found that all patients exhibited vitreous inflammation. Ocular features included focal hemorrhagic retinitis and peripheral retinal necrosis; in two eyes there were no focal but vasculitis and vitritis were manifested. In 64 percent of the eyes, inflammatory reactions developed in anterior segments. Seventy-three percent of the eyes had retinal vasculitis, including mostly arteries. Eleven patients were taking immunosuppressive medications; one was diagnosed with non-Hodgkin's lymphoma three months after CMV-linked uveitis onset; one had primary immunodeficiency disorder; two had diabetes; and three had no associated systemic diseases and no evidence of immune deficiency.

"CMV-associated infection of posterior eye segments can develop in patients without HIV infection who have variable degrees of compromised but may also occur in individuals who have no evidence of immune insufficiency," the authors write. "It may be that CMV infection located in posterior eye segments of patients without HIV infection is more frequent and has more variable clinical presentation than previously thought."

Explore further: Test approved to help treat common infection in transplant patients

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Test approved to help treat common infection in transplant patients

July 5, 2012
(HealthDay) -- The first DNA test to help doctors treat a common viral infection in people who have had a solid organ transplant has been approved by the U.S. Food and Drug Administration.

Researchers show long-term consequences of chronic virus infection

August 16, 2012
The cytomegalovirus (CMV) is a member of the herpesvirus family. Although most people carry CMV for life, it hardly ever makes them sick. Researchers from the Helmholtz Centre for Infection Research and from the USA have ...

How a virus might make you diabetic later in life

August 27, 2012
Cytomegalovirus (CMV) is one of the viruses that most infected people carry without ill effects. Once infected you are infected for life and, although it normally is dormant, it can become active again at any point in time. ...

Could probiotics help HIV patients?

January 16, 2013
Antiretroviral (ARV) drugs are the first line therapy for patients with HIV; however, ARV-treated, HIV-infected individuals still have a higher mortality rate than uninfected individuals. During the course of infection, HIV ...

Recommended for you

Study advances gene therapy for glaucoma

January 16, 2018
While testing genes to treat glaucoma by reducing pressure inside the eye, University of Wisconsin-Madison scientists stumbled onto a problem: They had trouble getting efficient gene delivery to the cells that act like drains ...

New study offers added hope for patients awaiting corneal transplants

January 9, 2018
New national research led by Jonathan Lass of Case Western Reserve University School of Medicine has found that corneal donor tissue can be safely stored for 11 days before transplantation surgery to correct eye problems ...

Diabetic blindness caused and reversed "trapped" immune cells in rodent retinas

January 3, 2018
Johns Hopkins researchers have discovered a cell signaling pathway in mice that triggers vision loss in patients with diabetic retinopathy and retinal vein occlusion – diseases characterized by the closure of blood vessels ...

Ophthalmologists increasingly dissatisfied with electronic health records

December 29, 2017
Ophthalmologists' use of electronic health records (EHR) systems for storing and accessing patients' medical histories more than doubled between 2006 and 2016, while their perceptions of financial and clinical productivity ...

Higher omega-3 fatty acid intake tied to lower glaucoma risk

December 26, 2017
(HealthDay)—Increased daily intake of ω-3 fatty acids is associated with lower odds of glaucoma, but higher levels of total polyunsaturated fatty acid (PUFA) intake are associated with higher odds of developing glaucoma, ...

Protein analysis allows for treatment of eye-disease symptoms with existing drugs

December 21, 2017
Demonstrating the potential of precision health, a team led by a researcher at the Stanford University School of Medicine has matched existing drugs to errant proteins expressed by patients with a rare eye disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.