Cytoskeletal dysregulation underlies Buruli ulcer formation

Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers.

In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP.

They found that excessive N-WASP activity caused defects in cell adhesion and migration that impaired the integrity of the skin.

Demangel and colleagues demonstrated that they could block the degradation process by administration of the N-WASP inhibitor wiskostatin.

These results reveal the of M. ulcerans and suggest that drugs that disrupt mycolactone/N-WASP interaction could be used to treat Buruli ulcers.

More information: Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation, J Clin Invest. doi:10.1172/JCI66576
Provided by Journal of Clinical Investigation
Citation: Cytoskeletal dysregulation underlies Buruli ulcer formation (2013, March 15) retrieved 18 February 2019 from https://medicalxpress.com/news/2013-03-cytoskeletal-dysregulation-underlies-buruli-ulcer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more