A nanogel-based treatment for lupus

Systemic lupus erythematosus (SLE) is disease in which the immune system mistakenly attacks healthy tissues, resulting in inflammation and tissue damage. Current treatments are focused on suppression of the immune system, but these therapies can leave patients vulnerable to infection.

In this issue of the , Tarek Fahmy and colleagues at Yale University report the development of a nanogel-based delivery system that targets an immunosuppressive drug (mycophenolic acid) directly to tissues associated with immune cells. A nanogel is composed of a polymer containing pores that can be loaded with .

Fahmy and colleagues tested the mycophenolic acid-loaded nanogel in a mouse model of lupus. Mice treated with the nanogel lived longer than untreated mice or mice treated with mycophenolic acid alone. Additionally, the onset of kidney damage, a common complication of lupus, was delayed in nanogel-treated mice.

These studies suggest that nanogel-based therapies may be useful in the treatment of SLE.


Explore further

A surprise mechanism uncovered in the development of lupus

More information: Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus, J Clin Invest. doi:10.1172/JCI65907
Citation: A nanogel-based treatment for lupus (2013, March 1) retrieved 18 July 2019 from https://medicalxpress.com/news/2013-03-nanogel-based-treatment-lupus.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more