First corneal transplant with pre-loaded donor tissue performed at Mass. Eye and Ear

May 7, 2013, Massachusetts Eye and Ear Infirmary

The first successful cornea transplant with donor endothelial tissue preloaded by an eye bank has been performed at Massachusetts Eye and Ear in Boston, Mass. Roberto Pineda II, M.D., Director of the Refractive Surgery Service at Mass. Eye and Ear, and an Associate Professor of Ophthalmology at Harvard Medical School, recently performed the groundbreaking transplant.

Dr. Pineda performed the surgery utilizing donor endothelial that was prepared and pre-loaded into EndoGlide (Angiotech Pharmaceuticals, Inc.) cartridges at the Lions Eye Institute for Transplant & Research (LEITR) in Tampa, FL.

According to Dr. Pineda, using preloaded donor tissue may minimize potential damage to the endothelial cells and, thus, may lead to better outcomes for the patient.

"Reducing any variables that could interfere with a patient's ability to successfully regain sight after surgery is significant," said Dr. Pineda. "The ultimate goal is to improve the quality of life for our patients," Dr. Pineda said.

A world-leading cornea expert and refractive surgeon at Mass. Eye and Ear, Dr. Pineda has collaborated with LEITR and Angiotech/Sharpoint for the last seven months to help develop the innovative procedure.

"I am pleased that - with Dr. Pineda leading these efforts - Mass. Eye and Ear is at the forefront of implementing an innovative technology that could greatly improve the quality of surgical outcomes for patients facing partial or complete vision loss," said Joan W. Miller, M.D., FARVO, Chief and Chair of at Mass. Eye and Ear and Harvard Medical School.

Last year, LEITR reported that eye banks are able to safely prepare and load corneal tissue into the EndoGlide cartridges. In a pre-clinical study presented at the 2012 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, corneal buttons pre-loaded by LEITR sustained an average of 9.07% endothelial cell damage, compared to 36.2% endothelial cell damage in control group tissue that was loaded into the insertion system on site. The difference in endothelial damage between the preloaded and control buttons was statistically significant (P = 0.004).

Explore further: Development of new cornea endothelial cell lines provides powerful tool for understanding corneal cell biology

Related Stories

Development of new cornea endothelial cell lines provides powerful tool for understanding corneal cell biology

December 27, 2012
Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. Cell loss due to aging or corneal endothelial disorders, such ...

Recommended for you

Study advances gene therapy for glaucoma

January 16, 2018
While testing genes to treat glaucoma by reducing pressure inside the eye, University of Wisconsin-Madison scientists stumbled onto a problem: They had trouble getting efficient gene delivery to the cells that act like drains ...

New study offers added hope for patients awaiting corneal transplants

January 9, 2018
New national research led by Jonathan Lass of Case Western Reserve University School of Medicine has found that corneal donor tissue can be safely stored for 11 days before transplantation surgery to correct eye problems ...

Diabetic blindness caused and reversed "trapped" immune cells in rodent retinas

January 3, 2018
Johns Hopkins researchers have discovered a cell signaling pathway in mice that triggers vision loss in patients with diabetic retinopathy and retinal vein occlusion – diseases characterized by the closure of blood vessels ...

Ophthalmologists increasingly dissatisfied with electronic health records

December 29, 2017
Ophthalmologists' use of electronic health records (EHR) systems for storing and accessing patients' medical histories more than doubled between 2006 and 2016, while their perceptions of financial and clinical productivity ...

Higher omega-3 fatty acid intake tied to lower glaucoma risk

December 26, 2017
(HealthDay)—Increased daily intake of ω-3 fatty acids is associated with lower odds of glaucoma, but higher levels of total polyunsaturated fatty acid (PUFA) intake are associated with higher odds of developing glaucoma, ...

Protein analysis allows for treatment of eye-disease symptoms with existing drugs

December 21, 2017
Demonstrating the potential of precision health, a team led by a researcher at the Stanford University School of Medicine has matched existing drugs to errant proteins expressed by patients with a rare eye disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.