DCIS Score quantifies risk of ipsilateral breast event

May 2, 2013

The ductal carcinoma in situ (DCIS) Score quantifies the risk of ipsilateral breast event (IBE) and invasive IBE risk, complements both traditional clinical and pathologic factors, and helps provide a new clinical tool to improve the process of selecting individualized treatment for women with DCIS who meet the criteria, according to a study published May 2 in the Journal of the National Cancer Institute.

Most women with newly diagnosed cases of DCIS are eligible for breast conservation surgery, either with or without. The risk of developing IBE after surgical excision without radiation has not been well defined by clinical and pathological characteristics for women with DCIS.

In order to determine the risk of developing IBE after surgical expression without radiation for women with DCIS, Lawrence J. Solin, M.D., of the Department of at the Albert Einstein Medical Center in Philadelphia and colleagues looked at the Oncotype DX assay which was used for patients with DCIS, treated with surgical excision without radiation in the Eastern Cooperative Oncology Group (ECOG) E5194 study, and looked at the association between the DCIS Score and the risk of developing IBE.

The researchers found that the continuous DCIS Score was statistically significantly associated with the risk of developing IBE. "The DCIS Score predicts the risks of local recurrence and invasive local recurrence and provides information that complements traditional clinical and pathologic factors for this study population of women with DCIS treated with surgical excision without radiation."

In an accompanying editorial, Christine D. Berg, M.D., formerly of the National Cancer Institute, writes that the assay does appear to be a step forward, but there were limitations, including that it was tested in a selected subset of patients. "The clinical applicability of this assay for all women who present with DCIS remains to be determined as the research was done on a highly selected patient group."

In another editorial, Thomas B. Julian, M.D., of Allegheny General Hospital in Pittsburgh, writes that the study and team should be applauded for efforts in introducing the DCIS score with an attempt to validate risk recurrence in patients with DCIS using tumor genetic profiling. "The DCIS Score should complement traditional clinical and pathologic factors used to guide decision making in the treatment of DCIS."

Explore further: New test predicts risk for recurrence for patients with DCIS

Related Stories

New test predicts risk for recurrence for patients with DCIS

December 7, 2011
In a significant advance for patients with ductal carcinoma in situ, researchers have developed and prospectively validated a multigene test to identify the risk for recurrence of breast cancer.

Combined RB and PTEN loss identifies DCIS primed for invasive breast cancer

November 28, 2012
The combined loss of two tumor suppressor genes, retinoblastoma (RB) and phosphatase and tensin homolog (PTEN) was shown to be strongly associated with progression of DCIS to invasive breast cancer, according to a study published ...

Accelerated radiation treatment effective for noninvasive breast cancer

June 29, 2012
Accelerated whole breast irradiation after lumpectomy is an effective treatment for ductal carcinoma in situ (DCIS), a very common early stage and noninvasive form of breast cancer, meaning many more breast cancer patients ...

Recommended for you

Anti-cancer chemotherapeutic agent inhibits glioblastoma growth and radiation resistance

July 24, 2017
Glioblastoma is a primary brain tumor with dismal survival rates, even after treatment with surgery, chemotherapy and radiation. A small subpopulation of tumor cells—glioma stem cells—is responsible for glioblastoma's ...

New therapeutic approach for difficult-to-treat subtype of ovarian cancer identified

July 24, 2017
A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.

Immune cells the missing ingredient in new bladder cancer treatment

July 24, 2017
New research offers a possible explanation for why a new type of cancer treatment hasn't been working as expected against bladder cancer.

Shooting the achilles heel of nervous system cancers

July 20, 2017
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center ...

Molecular changes with age in normal breast tissue are linked to cancer-related changes

July 20, 2017
Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history. However, the underlying biologic mechanisms through ...

Immune-cell numbers predict response to combination immunotherapy in melanoma

July 20, 2017
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.