Researcher discovers mechanism to slow tumor growth and metastasis in breast cancer

(Medical Xpress)—Wright State University Boonshoft School of Medicine professor Julian Gomez-Cambronero, Ph.D., and his research team have discovered a key protein that plays a critical role in the development of breast cancer tumors and the spread of the disease to the nearby lungs.

Cambronero's findings, published this month in the leading cancer journal Oncogene (click here for the report), attribute the cancer's growth to a protein called Phospholipase D (PLD). Cambronero and his team found that by introducing two new of PLD they could shrink tumor growth and reduce subsequent metastasis by around 70 percent.

"Although it's still early to tell, the application of these inhibitors to research in human tissue is the next step that could lead to better, less toxic treatments in the battle against ," said Cambronero, a professor of biochemistry and molecular biology.

Breast cancer kills more women in the United States each year—about 40,000—than any other type of cancer, according to the National Cancer Institute. The disease strikes an estimated 232,340 females each year and 2,240 males.


Explore further

Study finds new drug target for metastatic breast cancer

Journal information: Oncogene

Citation: Researcher discovers mechanism to slow tumor growth and metastasis in breast cancer (2013, July 9) retrieved 18 June 2019 from https://medicalxpress.com/news/2013-07-mechanism-tumor-growth-metastasis-breast.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more