Improving systematic reviews of animal studies will help translational medicine

July 16, 2013

Many new developments and initiatives have been introduced to improve the quality and translational value of animal research, and must continue with support from the wider scientific community. These are the conclusions of a new article in PLOS Medicine this week by Carlijn Hooijmans and colleagues from the Radboud University Nijmegen Medical Centre, Netherlands, who summarize these new developments.

Focusing on the quality of study conduct, reporting, and replication; systematic reviews and meta-analyses; and study registration, , and data sharing, the authors argue that systematic reviews of animal studies should be conducted routinely. Funding agencies should subsidize systematic reviews, not simply for transparency, but also to avoid waste of financial resources and unnecessary duplication of animal studies, they say, and an international register for animal studies should be established and funded.

"Improving the quality and translation of requires co-operation from the wider scientific community, journals, researchers, regulators, funding bodies, peer reviewers and patients," conclude the authors.

Explore further: New guidelines for writing abstracts will help authors summarise their research

More information: Hooijmans CR, Ritskes-Hoitinga M (2013) Progress in Using Systematic Reviews of Animal Studies to Improve Translational Research. PLoS Med 10(7): e1001482. doi:10.1371/journal.pmed.1001482

Related Stories

New guidelines for writing abstracts will help authors summarise their research

April 9, 2013
A new extension to the PRISMA guideline on reporting systemic reviews and meta-analyses (types of studies that analyse information from many studies) will help authors to give a more robust summary (abstract) of their study ...

New publication guidelines for systematic reviews from BMC Medicine

January 28, 2013
Two articles in BioMed Central's open access journal BMC Medicine by Geoff Wong, Trisha Greenhalgh and colleagues, propose publication guidelines for both realist synthesis and meta-narrative reviews.

How should systematic reviews consider evidence on harms?

May 3, 2011
Systematic reviews that attempt to assess the risk of harms (adverse effects) associated with specific therapies should consider a broad range of study designs, including both systematic reviews and observational studies. ...

ECO: Industry-funded reviews query sweet drink, obesity tie

May 14, 2013
(HealthDay)—Reviews that are funded by industry tend to find the evidence weak for a causal link between sugar-sweetened beverages (SSBs) and the increasing prevalence of obesity, while other reviews consider the evidence ...

Industry sponsorship leads to bias in reported findings of clinical trials

December 11, 2012
Studies reporting the results of industry sponsored clinical trials present a more favourable picture of the effects of drugs and medical devices than those reporting on non-industry sponsored trials, according to a new Cochrane ...

Reporting of dietary intake methods in obesity trials poor

August 23, 2012
(HealthDay)—More care needs to be taken in reporting dietary intake methods in childhood and adolescent obesity intervention trials in order to be able to better evaluate and replicate study methods, according to the results ...

Recommended for you

Drug therapy from lethal bacteria could reduce kidney transplant rejection

August 3, 2017
An experimental treatment derived from a potentially deadly microorganism may provide lifesaving help for kidney transplant patients, according to an international study led by investigators at Cedars-Sinai.

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...

Team eradicates hepatitis C in 10 patients following lifesaving transplants from infected donors

April 30, 2017
Ten patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease. The findings point to new strategies for increasing ...

'bench to bedside to bench': Scientists call for closer basic-clinical collaborations

March 24, 2017
In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory (JAX), National Human Genome Research ...

The ethics of tracking athletes' biometric data

January 18, 2017
(Medical Xpress)—Whether it is a FitBit or a heart rate monitor, biometric technologies have become household devices. Professional sports leagues use some of the most technologically advanced biodata tracking systems to ...

Financial ties between researchers and drug industry linked to positive trial results

January 18, 2017
Financial ties between researchers and companies that make the drugs they are studying are independently associated with positive trial results, suggesting bias in the evidence base, concludes a study published by The BMJ ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.