Not only bone density, but also quality of bone predicts fracture risk

August 5, 2013
Not only bone density, but also quality of bone predicts fracture risk
This image shows a bone biopsy. Credit: UEF, KUH

In a study carried out at the University of Eastern Finland, bone histomorphometry and infrared spectroscopy revealed abnormal bone properties in children with vertebral fractures and in children after solid organ transplantation. Bone compositional changes in children with vertebral fractures and after different types of organ transplantation have not been reported previously.

Bone samples were investigated using bone histomorphometry, a microscopic method that provides information about and remodelling. In children with , there were changes in bone composition, such as lower carbonate-to-phosphate-ratio and increased collagen maturity, which could explain the increased fracture risk. The results also suggest that in children who have undergone kidney, liver or , the various changes related to bone microarchitecture and turnover may be more important predictors of than lowered bone mineral density alone. Early detection of such changes in bone quality could help prevent fractures.

Osteoporosis is the most common characterized by abnormal bone formation and resorption which lead to increased risk of bone fractures. However, the present diagnostics based on the measurement of bone mineral density predict fractures only moderately. In addition to decreased , changes in bone quality could explain increased fragility related to osteoporosis. The present study confirmed that bone histomorphometry is needed in clinical practice to study remodelling balance in bone in certain patient groups.

Not only bone density, but also quality of bone predicts fracture risk
This image shows a bone biopsy. Credit: UEF, KUH

"Especially in clinically challenging scenarios where different treatment options are being considered, bone histomorphometry provides valuable information. An accurate diagnosis and choice of medication are especially important when treating paediatric patients," says Ms Inari Tamminen, MD, whose doctoral thesis on the topic was published in June.

The findings were originally published in Journal of Bone and Mineral Research and Journal of Bone and Mineral Metabolism.

The histomorphometry laboratory at the University of Eastern Finland in Kuopio is one of the few in the world analyzing clinical bone biopsies. More than 70 patient samples are analyzed annually. Over 30 years of expertise in quantitative histomorphometry have formed a solid basis for high quality research. Recent projects focus on paediatric patients with osteoporosis, genetic disorders and insufficiency fractures.

Explore further: Identification of a molecule linking bone loss and bone formation

Related Stories

Identification of a molecule linking bone loss and bone formation

August 1, 2013
Bone integrity requires skeletal remodeling, which involves both bone formation and resorption. It has been previously shown that the formation of new bone is triggered by degradation of older bone. However, it is unknown ...

Bone mineral density tx can be effective for young CF patients

June 4, 2013
(HealthDay)—For children and young adults with cystic fibrosis, adequate calcium intake plus calcifediol can improve bone mineral density, while alendronate can increase bone mineral density for some non-responders, according ...

Poorer bone health seen in black children with fractures

August 27, 2012
(HealthDay)—African-American children with forearm fractures are more likely to have vitamin D deficiency and lower bone mineral density than their peers without fractures, according to a study published online Aug. 27 ...

Patients who are engaged in their own care are more likely to reduce the risk of future fractures

July 8, 2013
People over the age of 50 who have suffered a fracture because of a slip or trip play a central role in making sure they get proper care to prevent a future fracture, a new study has found.

Reversal cells may tip the balance between bone formation and resorption in health and disease

June 6, 2013
By analyzing biopsy specimens from patients with postmenopausal osteoporosis and primary hyperparathyroidism, investigators have begun to pay increasing attention to "reversal cells," which prepare for bone formation during ...

Common osteoporosis drug slows formation of new bone

April 17, 2013
Although the drug zoledronic acid slows bone loss in osteoporosis patients, it also boosts levels of a biomarker that stops bone formation, according to a recent study accepted for publication in The Endocrine Society's Journal ...

Recommended for you

Zika virus stifles pregnant women's weakened immune system to harm baby, study finds

August 21, 2017
The Zika virus, linked to congenital birth defects and miscarriages, suppresses a pregnant woman's immune system, enabling the virus to spread and increasing the chances an unborn baby will be harmed, a Keck School of Medicine ...

Fatty liver can cause damage to other organs via crosstalk

August 21, 2017
Nonalcoholic fatty liver disease is increasingly common. Approximately every third adult in industrialized countries has a morbidly fatty liver. This not only increases the risk of chronic liver diseases such as liver cirrhosis ...

Novel approach to track HIV infection

August 18, 2017
Northwestern Medicine scientists have developed a novel method of tracking HIV infection, allowing the behavior of individual virions—infectious particles—to be connected to infectivity.

Faulty gene linked to obesity in adults

August 18, 2017
Groundbreaking new research linking obesity and metabolic dysfunction to a problem in the energy generators in cells has been published by researchers from the Harry Perkins Institute of Medical Research and The University ...

Two lung diseases killed 3.6 million in 2015: study

August 17, 2017
The two most common chronic lung diseases claimed 3.6 million lives worldwide in 2015, according to a tally published Thursday in The Lancet Respiratory Medicine.

New test differentiates between Lyme disease, similar illness

August 16, 2017
Lyme disease is the most commonly reported vector-borne illness in the United States. But it can be confused with similar conditions, including Southern Tick-Associated Rash Illness. A team of researchers led by Colorado ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.