Cancer research implies future for personalized medicine, reduction in animal testing

August 6, 2013, The Journal of Visualized Experiments

On August 6th, JoVE, the Journal of Visualized Experiments, will publish two new methods for scientists to study and treat tumor growth. The methods introduce a lab-born, human tissue structure with replicated human biochemistry – offering scientists the opportunity to grow, observe, and ultimately learn how to treat biopsied human tumor cells.

The University Hospital of Würzburg scientists behind the experiment have created a new version of the testing structures known as biological vascularized scaffolds (BioVaSc). Their three-dimensional human- are the first of their kind to be built with multiple human cell types. The structures offer two methods for study: a three-dimensional (3D) static system for short term testing that is beneficial for , and a dynamic system that introduces a flow-simulation to simulate actual conditions of the human body. This is especially helpful in long term studies of metastasis, or, the spreading of through the human vascular system.

"Our 3D tumor model is reducing or even replacing animal experiments," said engineer Jenny Reboredo. In their article, Reboredo and her colleagues explained that this based testing system could eliminate the potential for the misinterpretation that often accompanies animal testing. Furthermore, this method solves the shortfalls of typical in-vitro testing, which is limited by the lack of intercellular interactions.

This video shows tissue engineering of a human 3D in vitro tumor test system. Credit: The Journal of Visualized Experiements

The authors also suggest that their use of derived from is a "very important step towards personalized medicine." With the method the team has created, a lab could in the future take a biopsy of a cancer cell and do tests to find the most effective treatment before ever administering drugs to the human patient.

Further implications of Reboredo and her colleagues' work involve the use of a BioVaSc-type method for studying non-tumorous diseases. "In the long term we want to be able to develop disease models, especially for diseases where no animal models are available," Reboredo said.

When asked why she and her colleagues published in JoVE, Reboredo noted that their models "can be explained and visualized best in a movie [and] to publish in such a media is made possible by JoVE."

Explore further: New 3-D stem cell culture method published

Related Stories

New 3-D stem cell culture method published

March 2, 2012
Stem cells are the body's mechanics, repairing damaged tissues and organs. Because these cells are able to grow into any type of cell in the body, scientists believe they hold the key to groundbreaking new therapies. To help ...

Scientists scan the human heart to create digital anatomical library

April 18, 2013
On April 18th JoVE (Journal of Visualized Experiments) will publish a new video article by Dr. Paul A Iaizzo demonstrating the anatomical reconstruction of an active human heart. The research uses contrast-computed tomography ...

How the fluid between cells affects tumors

July 25, 2012
There are many factors that affect tumor invasion, the process where a tumor grows beyond the tissue where it first developed. While factors like genetics, tissue type and environmental exposure affect tumor metastasis and ...

Recommended for you

New approach attacks 'undruggable' cancers from the outside in

January 23, 2018
Cancer researchers have made great strides in developing targeted therapies that treat the specific genetic mutations underlying a patient's cancer. However, many of the most common cancer-causing genes are so central to ...

Study: Cells of three advanced cancers die with drug-like compounds that reverse chemo failure

January 23, 2018
Researchers at Southern Methodist University have discovered three drug-like compounds that successfully reverse chemotherapy failure in three of the most commonly aggressive cancers—ovarian, prostate and breast.

'Hijacker' drives cancer in some patients with high-risk neuroblastoma

January 23, 2018
Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome "hijacks" DNA that regulates other genes. The resulting insights ...

Enzyme inhibitor combined with chemotherapy delays glioblastoma growth

January 23, 2018
In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

Researchers identify a protein that keeps metastatic breast cancer cells dormant

January 23, 2018
A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light ...

Boosting cancer therapy with cross-dressed immune cells

January 22, 2018
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.