Early diabetes interventions may also reduce heart disease risk

August 27, 2013, The Endocrine Society

Two treatments that slow the development of diabetes also may protect people from heart disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Researchers examined the effect that making intensive lifestyle changes or taking the medication metformin had on and triglyceride levels. The study, part of the National Institutes of Health's Diabetes Prevention Program, found that both treatments induced positive changes in the level of particles that carry cholesterol and triglycerides through the blood stream. These changes could lower the chances of plaque building up in blood vessels.

"Cardiovascular disease is the most significant cause of death and disability in people with ," said the study's lead author, Ronald Goldberg, MD, of the University of Miami's Miller School of Medicine. "Our findings demonstrate that the same therapies used to slow the onset of diabetes also may help allay the risk of heart disease."

The randomized clinical trial analyzed blood samples from 1,645 people with impaired glucose tolerance. Participants were randomly assigned to one of three groups – one taking the medication metformin, another taking a placebo and a third undergoing an intensive lifestyle modification program. Researchers compared baseline blood samples from the start of the study to samples taken a year later to measure the interventions' effects. The study used advanced techniques to obtain a detailed picture of the various particles in the blood.

People who took part in the lifestyle modification program had lower levels of triglycerides and the particles that carry this kind of fat in the blood after a year. Both the metformin and lifestyle interventions were linked to reductions in the number of small low-density lipoprotein (LDL) particles, which carry cholesterol that may contribute to plaque formation, and increases in high-density lipoproteins (HDL), the form of cholesterol that reduces heart disease risk.

"Preventing or slowing the development of diabetes with these treatments also improves the cholesterol and triglyceride profile of a person's ," Goldberg said. "Thanks to the added benefits of existing diabetes interventions, we stand a better chance of lowering the risk of in this patient population."

Explore further: Controlling blood pressure, cholesterol may significantly cut heart disease risk

More information: The article, "Lifestyle and Metformin Treatment Favorable Influence Lipoprotein Sub-fraction Distribution in the Diabetes Prevention Program," will be published online on Aug. 27.

Related Stories

Controlling blood pressure, cholesterol may significantly cut heart disease risk

July 1, 2013
Simultaneously controlling your high blood pressure and high cholesterol may cut your risk for heart disease by half or more, according to new research in the American Heart Association journal Circulation. Yet fewer than ...

Metformin improves blood glucose levels and BMI in very obese children

December 10, 2012
Metformin therapy has a beneficial treatment effect over placebo in improving body mass index (BMI) and fasting glucose levels in obese children, according to a recent study accepted for publication in The Endocrine Society's ...

Type 2 diabetes progresses faster in kids, study finds

May 23, 2013
(HealthDay)—Type 2 diabetes is more aggressive in children than adults, with signs of serious complications seen just a few years after diagnosis, new research finds.

People with pre-diabetes who drop substantial weight may ward off type 2 diabetes

July 16, 2013
People with pre-diabetes who lose roughly 10 percent of their body weight within six months of diagnosis dramatically reduce their risk of developing type 2 diabetes over the next three years, according to results of research ...

Secondhand smoke presents greater threat to teen girls than boys

April 30, 2013
When teenage girls are exposed to secondhand smoke at home, they tend to have lower levels of the "good" form of cholesterol that reduces heart disease risk, according to a recent study accepted for publication in The Endocrine ...

Pain reliever lowers blood sugar in type 2 diabetics, study says

July 1, 2013
(HealthDay)— An aspirin-like drug appears to lower blood sugar in people with type 2 diabetes, according to new research.

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.