MRI-guided ultrasound surgery beneficial for essential tremor

MRI-guided ultrasound surgery beneficial for essential tremor
Patients with severe, medication-refractory essential tremor benefit from the use of transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy, according to a study published in the Aug. 15 issue of the New England Journal of Medicine.

(HealthDay)—Patients with severe, medication-refractory essential tremor benefit from the use of transcranial magnetic resonance imaging (MRI)-guided focused ultrasound thalamotomy, according to a study published in the Aug. 15 issue of the New England Journal of Medicine.

W. Jeffrey Elias, M.D., from the University of Virginia Health Sciences Center in Charlottesville, and colleagues investigated the use of transcranial MRI-guided thalamotomy for treatment of in an open-label uncontrolled study involving 15 patients with severe, medication-refractory essential tremor. Transcranial MRI-guided focused ultrasound was used to target the unilateral ventral intermediate nucleus of the thalamus. Safety data were recorded and the effectiveness of was measured using the Clinical Rating Scale for Tremor. Patients' perceptions of treatment efficacy were assessed using the Quality of Life in Essential Tremor Questionnaire.

The researchers found that, in all patients, thermal ablation of the thalamic target occurred. Transient sensory, cerebellar, motor, and speech abnormalities were adverse effects of the procedures, with four patients experiencing persistent paresthesias. From baseline to 12 months, scores for hand tremor improved significantly, from 20.4 to 5.2. There were also significant improvements in total tremor scores (54.9 to 24.3), disability scores (18.2 to 2.8), and quality-of-life scores (37 to 11 percent).

"In this pilot study, essential tremor improved in 15 patients treated with MRI-guided focused ultrasound thalamotomy," the authors write. "Large, randomized, controlled trials will be required to assess the procedure's efficacy and safety."

The study was funded by the Focused Ultrasound Surgery Foundation.


Explore further

Focused ultrasound for treating Parkinson's disease to be tested

More information: Full Text (subscription or payment may be required)
Journal information: New England Journal of Medicine

Copyright © 2013 HealthDay. All rights reserved.

Citation: MRI-guided ultrasound surgery beneficial for essential tremor (2013, August 15) retrieved 19 November 2019 from https://medicalxpress.com/news/2013-08-mri-guided-ultrasound-surgery-beneficial-essential.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments