Prolactin reduces arthritis inflammation

August 1, 2013, Journal of Clinical Investigation

Inflammatory joint diseases such as rheumatoid arthritis are the result of cartilage damage and loss. Chondrocytes are the only cells that are found in cartilage and their death is linked to decreased cartilage health.

In this issue of the Journal of Clinical Investigation, Carmen Clapp and colleagues at the National University of Mexico identify prolactin as a potential treatment for inflammatory joint disease.

Prolactin treatment prevented chondrocyte death and associated cartilage degradation. In a rat model of inflammatory arthritis, prolactin treatment reduced inflammation, bone erosion, joint swelling, and pain.

This study indicates that prolactin therapy has the potential to relieve many symptoms associated with rheumatoid arthritis and other inflammatory-related diseases.

Explore further: Can stem cells help those with arthritis?

More information: Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis, J Clin Invest. doi:10.1172/JCI69485

Related Stories

Can stem cells help those with arthritis?

April 28, 2013
Stems cells taken from just a few grams of body fat are a promising weapon against the crippling effects of osteoarthritis.

Naturally occurring molecule in the body may have important consequences for treating osteoarthritis

July 11, 2013
UK scientists have found a naturally occurring molecule in the body which may have important consequences for treating osteoarthritis. Researchers from The University of Manchester and the University of Westminster have found ...

Scientists discover promising protein to treat osteoarthritis

July 25, 2013
New research from Queen Mary, University of London suggests that a protein found predominantly in healthy cartilage, a type of tissue that allows the smooth movement of joints, could hold the key to treating osteoarthritis.

Researcher examines the relationship between gum disease and arthritis

October 16, 2012
Adelaide scientists have found that mice with gum disease develop worse arthritis.

Possible new approach to fighting chronic inflammatory diseases

July 30, 2012
(Medical Xpress) -- Researchers from The University of Queensland's Institute for Molecular Bioscience have discovered a potential new approach to treating chronic inflammatory diseases such as arthritis.

Recommended for you

Joint resolution: A link between Huntington's disease and rheumatoid arthritis

May 15, 2018
Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common ...

Get off the golf cart if you have knee osteoarthritis

April 28, 2018
From presidents to retirees, more than 17 million people over the age of 50 golf regularly. Knee osteoarthritis, which causes swelling, pain and difficulty moving the joint, is one of the leading causes of disability in this ...

How environmental pollutants and genetics work together in rheumatoid arthritis

April 19, 2018
It has been known for more than three decades that individuals with a particular version of a gene—human leukocyte antigen (HLA)—have an increased risk for rheumatoid arthritis.

The bugs in your gut could make you weak in the knees

April 19, 2018
Bacteria in the gut, known as the gut microbiome, could be the culprit behind arthritis and joint pain that plagues people who are obese, according to a new study published today in JCI Insight.

Researchers identify peptide produced during cartilage deterioration as a potential source of osteoarthritis pain

April 11, 2018
Osteoarthritis is one of the most common causes of chronic pain in the world. More than 30 million people in the United States alone suffer from osteoarthritis, or OA, which can affect any moveable joint of the body, including ...

Flare-responsive hydrogel developed to treat arthritis

April 3, 2018
Arthritis flares - the unpredictable and often sudden worsening of arthritis symptoms—can be debilitating. These episodes can make the management of inflammatory arthritis, which includes rheumatoid arthritis and psoriatic ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.