Prolactin reduces arthritis inflammation

Inflammatory joint diseases such as rheumatoid arthritis are the result of cartilage damage and loss. Chondrocytes are the only cells that are found in cartilage and their death is linked to decreased cartilage health.

In this issue of the Journal of Clinical Investigation, Carmen Clapp and colleagues at the National University of Mexico identify prolactin as a potential treatment for inflammatory joint disease.

Prolactin treatment prevented chondrocyte death and associated cartilage degradation. In a rat model of inflammatory arthritis, prolactin treatment reduced inflammation, bone erosion, joint swelling, and pain.

This study indicates that prolactin therapy has the potential to relieve many symptoms associated with rheumatoid arthritis and other inflammatory-related diseases.


Explore further

Can stem cells help those with arthritis?

More information: Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis, J Clin Invest. doi:10.1172/JCI69485
Citation: Prolactin reduces arthritis inflammation (2013, August 1) retrieved 17 September 2019 from https://medicalxpress.com/news/2013-08-prolactin-arthritis-inflammation.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more