Brain still injured from concussion after symptoms fade

November 20, 2013

After a mild concussion, special brain scans show evidence of brain abnormalities four months later, when symptoms from the concussion have mostly dissipated, according to research published in the November 20, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology.

"These results suggest that there are potentially two different modes of recovery for concussion, with the memory, thinking and behavioral symptoms improving more quickly than the physiological injuries in the brain," said study author Andrew R. Mayer, PhD, of the Mind Research Network and University of New Mexico School of Medicine in Albuquerque.

Mayer further suggests that healing from concussions may be similar to other body ailments such as recovering from a burn. "During recovery, reported symptoms like pain are greatly reduced before the body is finished healing, when the tissue scabs. These finding may have important implications about when it is truly safe to resume physical activities that could produce a second concussion, potentially further injuring an already vulnerable brain."

Mayer noted that standard brain scans such as CT or MRI would not pick up on these subtle changes in the brain. "Unfortunately, this can lead to the common misperception that any persistent symptoms are psychological."

The study compared 50 people who had suffered a mild concussion to 50 healthy people of similar age and education. All the participants had tests of their memory and and other symptoms such as anxiety and depression two weeks after the concussion, as well as . Four months after the concussion, 26 of the patients and 26 controls repeated the tests and scans.

The study found that two weeks after the injury the people who had concussions had more self-reported problems with memory and thinking skills, physical problems such as headaches and dizziness, and emotional problems such as depression and anxiety than people who had not had concussions. By four months after the injury, the were significantly reduced by up to 27 percent.

The people who had concussions also had evidence of abnormalities in the gray matter in the frontal cortex area of both sides of the brain, based on the diffusion tensor imaging scans. The increase equated to about 10 percent compared to the in the study. These abnormalities were still apparent four months after the . In contrast, there was no evidence of cellular loss on scans.

Mayer said possible explanations for the could be cytotoxic edema, which results from changes in where fluids are located in and around brain cells, or reactive gliosis, which is the change in glial cells' shape in response to damage to the central nervous system.

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joanna_lane2
not rated yet Nov 25, 2013
It's very significant that these changes persist. Yet when they are found, why does nobody screen these patients for PTHP? It's hugely under-diagnosed, and treatable. Treatment might make a real difference to their recovery. See http://bit.ly/1aaznvZ ('lethal time bomb that can be caused by a head injury') and this link http://bit.ly/18rSvpW for an example of how effective treatment can be.

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