Angiogenic factor secretion by melanocytes associated with pigmentation leve

December 20, 2013

The decreased vision loss that accompanies age-related macular degeneration (AMD) is associated with abnormal blood vessel growth in the eye. Frequencies of AMD development are different among racial backgrounds, with occurrence of AMD highest among individuals of mixed European decent. Furthermore, other diseases associated with dysfunctional neovascularization occur at different frequencies depending on racial background, suggesting a connection between pigmentation and susceptibility to angiogenic disease.

In this issue of the Journal of Clinical Investigation, Irit Adini and colleagues at the Harvard Medical School determined that melanocytes from light-skinned humans and albino mice secrete high levels of fibromodulin and that fibromodulin promotes angiogenesis.

In a companion commentary, Christopher Kontos of Duke University discusses the potential for fibromodulin to be both a useful biomarker and a therapeutic target for diseases associated with increased vascularization.

Explore further: Impaired autophagy associated with age-related macular degeneration

More information: Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment, J Clin Invest. DOI: 10.1172/JCI69404
More than skin deep: connecting melanocyte pigmentation and angiogenic diseases, J Clin Invest. 2014;124(1):76–79. DOI: 10.1172/JCI73559

Related Stories

Impaired autophagy associated with age-related macular degeneration

August 21, 2013
A new study published in the prestigious PLoS One journal changes our understanding of the pathogenesis of age-related macular degeneration (AMD). The researchers found that degenerative changes and loss of vision are caused ...

Team finds potential topical treatment for macular degeneration

October 9, 2013
Researchers from Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences have identified a possible topical treatment for age-related macular degeneration (AMD) in a study of mice that shows ...

Findings support link between hsCRP, macular degeneration

February 8, 2013
(HealthDay)—Pooled results from five cohorts confirm that high levels of high-sensitivity C-reactive protein (hsCRP) correlate with increased future risk of age-related macular degeneration (AMD), according to research ...

Age-related macular degeneration treatment works even with other eye problem

November 11, 2012
The primary treatment for wet macular degeneration, a chronic eye condition that causes vision loss, is effective even if patients have macular traction problems, a Mayo Clinic study shows. The findings will be presented ...

Genotyping IDs long-term risk of macular degeneration

November 13, 2012
(HealthDay)—Genotyping of two genetic risk alleles can be used to estimate the long-term risk of early and late age-related macular degeneration (AMD), but knowing the phenotype is important in assessing risk when early ...

Recommended for you

Combination of type 2 diabetes and sleep apnoea indicates eyesight loss within four years

July 4, 2017
Research led by the University of Birmingham has discovered that patients who suffer from both Type 2 diabetes and obstructive sleep apnoea are at greater risk of developing a condition that leads to blindness within an average ...

Nearly 60% of pinkeye patients receive antibiotic eye drops, but they're seldom necessary

June 28, 2017
A new study suggests that most people with acute conjunctivitis, or pinkeye, are getting the wrong treatment.

Magnetic implants used to treat 'dancing eyes'

June 26, 2017
A research team has successfully used magnets implanted behind a person's eyes to treat nystagmus, a condition characterised by involuntary eye movements.

Drug shows promise against vision-robbing disease in seniors

June 21, 2017
An experimental drug is showing promise against an untreatable eye disease that blinds older adults—and intriguingly, it seems to work in patients who carry a particular gene flaw that fuels the damage to their vision.

Reproducing a retinal disease on a chip

June 15, 2017
Approximately 80% of all sensory input is received via the eyes, so suffering from chronic retinal diseases that lead to blindness causes a significant decrease in the quality of life (QOL). And because retinal diseases are ...

New gene therapy for vision loss proven safe in humans

May 16, 2017
In a small and preliminary clinical trial, Johns Hopkins researchers and their collaborators have shown that an experimental gene therapy that uses viruses to introduce a therapeutic gene into the eye is safe and that it ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.