Two SNPs predict lithium response in bipolar I disorder

December 31, 2013
Two SNPs predict lithium response in bipolar I disorder

(HealthDay)—For patients with bipolar I disorder, two single nucleotide polymorphisms (SNPs) in glutamate decarboxylase-like protein 1 (GADL1) predict response to lithium, according to a study published online Dec. 25 in the New England Journal of Medicine.

Noting that many patients with bipolar disorders do not respond to lithium therapy, Chien-Hsiun Chen, Ph.D., from the Institute of Biomedical Sciences in Taipei, Taiwan, and colleagues assessed the response to in subgroups from a sample of 1,761 patients of Han Chinese descent with bipolar I disorder. A genome-wide association study was performed on a subgroup of 294 patients with bipolar I disorder who were receiving lithium. The SNPs with the strongest association with response were assessed in a replication sample of 100 patients and then in a follow-up sample of 24 patients. GADL1 was sequenced in 94 patients with a response to lithium and 94 without.

The researchers found that the strongest associations were seen for rs17026688 and rs17026651 in the genome-wide association study and in the replication sample of 100 patients. The sensitivity for predicting a response to lithium was 93 percent for these two SNPs, and they were able to differentiate between patients with a good and poor response in the follow-up cohort.

"Genetic variations in GADL1 are associated with the response to lithium maintenance treatment for bipolar I disorder in patients of Han Chinese descent," the authors write.

Explore further: The hunt for a successor to lithium for bipolar disorder

More information: Abstract
Full Text

Related Stories

The hunt for a successor to lithium for bipolar disorder

March 27, 2013
Toxicity problems and adverse side effects when taking lithium, the mainstay medication for treating bipolar disorder, are fostering a scientific hunt for insights into exactly how lithium works in the body—with an eye ...

Body clocks may hold key for treatment of bipolar disorder

March 13, 2012
Scientists have gained insight into why lithium salts are effective at treating bipolar disorder in what could lead to more targeted therapies with fewer side-effects.

Lithium reduces risk of suicide in people with mood disorders

June 28, 2013
The authors say the drug "seems to reduce the risk of death and suicide by more than 60% compared with placebo" and suggest this review "reinforces lithium as an effective agent to reduce the risk of suicide in people with ...

Giving lithium to those who need it

September 21, 2012
Lithium is a 'gold standard' drug for treating bipolar disorder, however not everyone responds in the same way. New research published in BioMed Central's open access journal Biology of Mood & Anxiety Disorders finds that ...

Recommended for you

Gene associated with schizophrenia risk regulates neurodevelopment

September 25, 2017
A gene associated with the risk of schizophrenia regulates critical components of early brain development, according to a new study led by researchers from Penn State University. The gene is involved in the translation of ...

For a better 'I,' there needs to be a supportive 'we'

September 25, 2017
If you're one of those lucky individuals with high motivation and who actively pursues personal growth goals, thank your family and friends who support you.

Child abuse affects brain wiring

September 25, 2017
Researchers from the McGill Group for Suicide Studies, based at the Douglas Mental Health University Institute and McGill University's Department of Psychiatry, have just published research in the American Journal of Psychiatry ...

Babies can learn that hard work pays off

September 21, 2017
If at first you don't succeed, try, try again. A new study from MIT reveals that babies as young as 15 months can learn to follow this advice. The researchers found that babies who watched an adult struggle at two different ...

Study links brain inflammation to suicidal thinking in depression

September 21, 2017
Patients with major depressive disorder (MDD) have increased brain levels of a marker of microglial activation, a sign of inflammation, according to a new study in Biological Psychiatry by researchers at the University of ...

Oxytocin turns up the volume of your social environment

September 20, 2017
Before you shop for the "cuddle" hormone oxytocin to relieve stress and enhance your social life, read this: a new study from the University of California, Davis, suggests that sometimes, blocking the action of oxytocin in ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.