Review: Recently diagnosed diabetes linked to pancreatic CA

March 24, 2014
Review: recently diagnosed diabetes linked to pancreatic CA

(HealthDay)—There is a strong association between pancreatic ductal adenocarcinoma (PDAC) and recently diagnosed diabetes mellitus (DM), according to a systematic review and meta-analysis published in the March issue of the Annals of Surgical Oncology.

Pikli Batabyal, M.B.B.S., from the University of Melbourne in Australia, and colleagues conducted a and identified 88 independent studies (50 cohort and 39 case-control) examining the association between DM and PDAC. A "random effects" approach was used to calculate summary estimates for case-control and cohort studies.

The researchers found that the overall summary-combined relative risk was 1.97, with considerable heterogeneity observed that could not be attributed to analyses of any subgroup. The greatest risk of PDAC was seen early after DM diagnosis, but risk remained elevated for a prolonged period. There was variation in the individual-level relative risk from 6.69 at less than one year to 1.36 at 10 years.

"The results demonstrate a strong association between PDAC and recently diagnosed DM, which may be attributed to a paraneoplastic effect," the authors write. "Selective screening of patients with new-onset DM for PDAC needs to be considered."

Explore further: New findings show link between diabetes and pancreatic cancer

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

New findings show link between diabetes and pancreatic cancer

March 14, 2014
In a new study published today in Annals of Surgical Oncology, clinicians worked with mathematicians to review data from 1973 to 2013 to conclude there was a time-dependent link between being diagnosed with diabetes and pancreatic ...

Psoriasis tied to increased risk of new-onset diabetes

March 27, 2013
(HealthDay)—Psoriasis is significantly tied to an increased risk of new-onset diabetes mellitus (DM), according to a study published online March 14 in Diabetes Care.

Specificity up with stereoscopic mammography for CA detection

January 18, 2013
(HealthDay)—Three-dimensional stereoscopic digital mammography (DM) significantly improves the specificity and accuracy of breast cancer detection, with a lower patient recall rate and a sensitivity comparable to that of ...

Diabetes, poor glucose control associated with greater cognitive decline in older adults

June 18, 2012
Among well-functioning older adults without dementia, diabetes mellitus (DM) and poor glucose control among those with DM are associated with worse cognitive function and greater cognitive decline, according to a report published ...

Risk of new-onset diabetes varies with different statins

April 11, 2013
(HealthDay)—Different types and doses of statins seem to correlate with distinct risks of developing new-onset diabetes mellitus (DM), according to a meta-analysis published in the April 15 issue of The American Journal ...

Recommended for you

Outdoor light at night linked with increased breast cancer risk in women

August 17, 2017
Women who live in areas with higher levels of outdoor light at night may be at higher risk for breast cancer than those living in areas with lower levels, according to a large long-term study from Harvard T.H. Chan School ...

Scientists develop novel immunotherapy technology for prostate cancer

August 17, 2017
A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific ...

Toxic formaldehyde is produced inside our own cells, scientists discover

August 16, 2017
New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment - it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing ...

Cell cycle-blocking drugs can shrink tumors by enlisting immune system in attack on cancer

August 16, 2017
In the brief time that drugs known as CDK4/6 inhibitors have been approved for the treatment of metastatic breast cancer, doctors have made a startling observation: in certain patients, the drugs—designed to halt cancer ...

Researchers find 'switch' that turns on immune cells' tumor-killing ability

August 16, 2017
Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule ...

Popular immunotherapy target turns out to have a surprising buddy

August 16, 2017
The majority of current cancer immunotherapies focus on PD-L1. This well studied protein turns out to be controlled by a partner, CMTM6, a previously unexplored molecule that is now suddenly also a potential therapeutic target. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.