Fever induction reduces tumors

March 19, 2014

Peregrine Laziosi (1265–1345), an Italian priest, became the patron saint of cancer patients when the tumour in his left leg miraculously disappeared after he developed a fever. Although it is known since a long time that elevated body temperature can cause tumours to regress, the underlying molecular mechanisms are still largely enigmatic.

Thomas Turner, a recent Cancer Biology graduate from Bangor University, and Dr Thomas Caspari, a researcher based in the School of Biological Sciences at Bangor University published one of the first comprehensive reviews of this topic in the Royal Society Journal Open Biology.

Dr Thomas Caspari says: "The induction of a fever by injecting patients with inactivated bacteria, which became known as Coley`s Toxin, was a very successful anti-cancer therapy in the 19th century. The healing power of heat has now been re-discovered and is used to treat patients with to great effect. This review article summarises our current scientific understanding of how heat kills cancer cells. It is also great to see the work of an undergraduate student published in a scientific journal with high international reputation. This is a good example of how Bangor University incorporates research into teaching."

Explore further: How heat helps to treat cancer

More information: "Thomas Turner and Thomas Caspari, When heat casts a spell on the DNA damage checkpoints." Open Biol. March 2014 4:140008; DOI: 10.1098/rsob.140008 2046-2441

Related Stories

How heat helps to treat cancer

August 8, 2012
Research at Bangor University has identified a switch in cells that may help to kill tumors with heat. Prostate cancer and other localized tumors can be effectively treated by a combination of heat and an anti-cancer drug ...

Bacteria may assist the immune system response against cancer

March 3, 2014
(Medical Xpress)—Recent research from the University of Otago shows that bacteria may assist the body's immune system response against cancer cells and help fight tumours like melanoma.

New imaging approach fast tracks drug testing for incurable prostate cancer

March 17, 2014
Cancer Research UK-funded scientists have developed a new way to test the effectiveness of a drug for prostate cancer that has spread to the bone, which is currently incurable, according to research published in the Journal ...

Acidic tumour pH inhibits drug effect

February 11, 2014
Low pH in tumours counteracts the desired effect of the drug chloroquine, according to a new study from Karolinska Institutet in Sweden. The results, which are published in the journal Autophagy, might explain possible lack ...

Tumour expression of leptin associated with chemotherapy resistance

February 26, 2014
Patients with the most common type of oesophageal cancer are less likely to respond to chemotherapy when their tumours are high in a protein called leptin, according to research published in the British Journal of Cancer.

New findings show link between diabetes and pancreatic cancer

March 14, 2014
In a new study published today in Annals of Surgical Oncology, clinicians worked with mathematicians to review data from 1973 to 2013 to conclude there was a time-dependent link between being diagnosed with diabetes and pancreatic ...

Recommended for you

Discovery could lead to better results for patients undergoing radiation

July 19, 2017
More than half of cancer patients undergo radiotherapy, in which high doses of radiation are aimed at diseased tissue to kill cancer cells. But due to a phenomenon known as radiation-induced bystander effect (RIBE), in which ...

Definitive genomic study reveals alterations driving most medulloblastoma brain tumors

July 19, 2017
The most comprehensive analysis yet of medulloblastoma has identified genomic changes responsible for more than 75 percent of the brain tumors, including two new suspected cancer genes that were found exclusively in the least ...

Novel CRISPR-Cas9 screening enables discovery of new targets to aid cancer immunotherapy

July 19, 2017
A novel screening method developed by a team at Dana-Farber/Boston Children's Cancer and Blood Disorders Center—using CRISPR-Cas9 genome editing technology to test the function of thousands of tumor genes in mice—has ...

Combining CAR T cells with existing immunotherapies may overcome resistance in glioblastomas

July 19, 2017
Genetically modified "hunter" T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor ...

How CD44s gives brain cancer a survival advantage

July 19, 2017
Understanding the mechanisms that give cancer cells the ability to survive and grow opens the possibility of developing improved treatments to control or cure the disease. In the case of glioblastoma multiforme, the deadliest ...

New way found to boost immunity in fight cancer and infections

July 19, 2017
An international research team led by Université de Montréal medical professor Christopher Rudd, director of research in immunology and cell therapy at Maisonneuve-Rosemont Hospital Research Centre, has identified a key ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.