Penicillin 'allergy' complicates inpatient care

March 18, 2014
Penicillin 'Allergy' complicates inpatient care

(HealthDay)—Patients with a history of penicillin "allergy," even though that may be inaccurate, spend more time in the hospital and have a greater risk of acquiring antibiotic-associated infections, according to research published in the Journal of Allergy and Clinical Immunology.

Eric Macy, M.D., of the Southern California Permanente Medical Group in San Diego, and Richard Contreras, of the Kaiser Permanente Health Care Program in Pasadena, Calif., conducted a retrospective, matched cohort study involving 51,582 subjects with penicillin "allergy" who were admitted to Kaiser Foundation hospitals in Southern California in 2010 through 2012. Each subject was matched to two control subjects by age, sex, date of admission, and discharge diagnosis.

The researchers found that patients labeled with , compared with control subjects, averaged 0.59 more total hospital days (95 percent confidence interval [CI], 0.47 to 0.71). Case subjects received treatment with significantly more of each of the following antibiotics: fluoroquinolones, clindamycin, and vancomycin. Compared with , case subjects experienced more Clostridium difficile infections (23.4 percent; 95 percent CI, 15.6 to 31.7 percent), methicillin-resistant Staphylococcus aureus infections (14.1 percent; 95 percent CI, 7.1 to 21.6 percent), and vancomycin-resistant Enterococcus infections (30.1 percent; 95 percent CI, 12.5 to 50.4 percent).

"A penicillin 'allergy' history, although often inaccurate, is not a benign finding at hospital admission," the authors write.

The Kaiser Permanente Health Care Program and ALK-Abelló funded the study. Both study authors disclosed financial ties to ALK-Abelló.

Explore further: Coffee consumption linked with reduced risk of diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Coffee consumption linked with reduced risk of diabetes

February 17, 2014
(HealthDay)—Higher consumption of coffee is associated with lower risk of type 2 diabetes, according to research published in the February issue of Diabetes Care.

Psoriasis tied to 14 other autoimmune diseases

June 15, 2012
(HealthDay) -- Patients with psoriasis have significantly higher odds for having at least one of 14 other autoimmune diseases, according to a study published online June 4 in the Journal of the American Academy of Dermatology.

Stage III/IV melanoma patients at risk for new primaries

December 10, 2013
(HealthDay)—Patients with stage III or IV melanoma who have not received treatment with BRAF inhibitors remain at risk for developing new primary melanomas (NPMs), although the incidence rates are lower than those observed ...

Melanoma risk up in IBD independent of biologic therapy

January 31, 2014
(HealthDay)—Inflammatory bowel disease (IBD) is associated with an increased risk of melanoma, independent of the use of biologic therapy, according to research published in the February issue of Clinical Gastroenterology ...

Metformin use doesn't cut incidence of bladder cancer

February 11, 2014
(HealthDay)—For patients with type 2 diabetes, metformin use is not associated with a significantly reduced risk of bladder cancer, according to a study published online Feb. 4 in Diabetes Care.

Osteoporosis / Osteopenia prevalent in chronic pancreatitis

January 31, 2014
(HealthDay)—Sixty-five percent of patients with chronic pancreatitis have osteoporosis or osteopenia, according to a meta-analysis published in the February issue of Clinical Gastroenterology and Hepatology.

Recommended for you

Novel genomic tools provide new insight into human immune system

January 19, 2018
When the body is under attack from pathogens, the immune system marshals a diverse collection of immune cells to work together in a tightly orchestrated process and defend the host against the intruders. For many decades, ...

Genomics reveals key macrophages' involvement in systemic sclerosis

January 18, 2018
A new international study has made an important discovery about the key role of macrophages, a type of immune cell, in systemic sclerosis (SSc), a chronic autoimmune disease which currently has no cure.

First vaccine developed against grass pollen allergy

January 18, 2018
Around 400 million people worldwide suffer in some form or other from a grass pollen allergy (rhinitis), with the usual symptoms of runny nose, cough and severe breathing problems. In collaboration with the Viennese firm ...

Researchers discover key driver of atopic dermatitis

January 17, 2018
Severe eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that is driven by an allergic reaction. In their latest study, researchers at La Jolla Institute reveal an important player that promotes ...

Who might benefit from immunotherapy? New study suggests possible marker

January 16, 2018
While immunotherapy has made a big impact on cancer treatment, the fact remains that only about a quarter of patients respond to these treatments.

Researchers identify new way to unmask melanoma cells to the immune system

January 16, 2018
system, which enables these deadly skin cancers to grow and spread.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.