Stage III/IV melanoma patients at risk for new primaries

Stage III/IV melanoma patients at risk for new primaries

(HealthDay)—Patients with stage III or IV melanoma who have not received treatment with BRAF inhibitors remain at risk for developing new primary melanomas (NPMs), although the incidence rates are lower than those observed in studies of dabrafenib and vemurafenib, according to research published online Dec. 2 in the Journal of Clinical Oncology.

Lisa Zimmer, M.D., of the University Duisburg-Essen in Germany, and colleagues followed a large cohort of patients with stage III or IV , who were not treated with a BRAF inhibitor, to assess the background incidence of spontaneous NPMs.

The researchers found that the cumulative incidence rate of NPMs after diagnosis of stage III melanoma was 1.2 percent (95 percent confidence interval [CI], 0.86 to 1.51 percent) at six months, 1.8 percent (95 percent CI, 1.44 to 2.26 percent) at one year, and 5.9 percent (95 percent CI, 5.08 to 6.74 percent) at 10 years. The cumulative incidence rate of NPMs after diagnosis of stage IV melanoma was 0.2 percent (95 percent CI, 0.07 to 0.36 percent) at three months, 0.3 percent (95 percent CI, 0.15 to 0.51 percent) at six months, and 0.4 percent (95 percent CI, 0.25 to 0.7 percent) at one year. A higher incidence of NPMs was observed in patients with stage III/IV melanoma who were male or who had a history of multiple primary melanomas.

"Patients with stage III and stage IV melanoma remain at risk for development of further primary melanomas, particularly if they have a history of multiple primary melanomas before stage III or IV disease," the authors write. "Although the are lower than those observed in the studies of dabrafenib and vemurafenib, the results must be compared with caution because of the more frequent and thorough dermatologic assessments in the BRAF inhibitor studies."

Several authors disclosed financial ties to pharmaceutical companies, including manufacturers of BRAF inhibitors.


Explore further

Studies identify cell-signaling pathway alterations responsible for melanoma drug resistance

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Journal of Clinical Oncology

Copyright © 2013 HealthDay. All rights reserved.

Citation: Stage III/IV melanoma patients at risk for new primaries (2013, December 10) retrieved 11 November 2019 from https://medicalxpress.com/news/2013-12-stage-iiiiv-melanoma-patients-primaries.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments