Three DNA methylation markers ID recurrence in bladder cancer

April 2, 2014
Three DNA methylation markers ID recurrence in bladder cancer

(HealthDay)—For patients with noninvasive urothelial carcinoma, three DNA methylation markers are able to accurately predict tumor recurrence, according to a study published in the April 1 issue of Clinical Cancer Research.

Sheng-Fang Su, from USC Norris Comprehensive Cancer Center at the University of Southern California in Los Angeles, and colleagues analyzed DNA methylation levels of six markers in 368 urine sediment samples from 90 patients with noninvasive to assess their use in longitudinal surveillance. Five-fold cross-validation was used to identify the optimum marker combination, which was then validated in separate samples.

The researchers identified a panel of three markers which were able to discriminate between patients with and without recurrence. The area under the curve was 0.90 in the testing set and 0.95 in the validation set, while sensitivity was 86 and 89 percent and specificity 80 and 97 percent, respectively. Tumor recurrence was reliably predicted by the three-marker test in 80 percent of patients, which was superior to cytology and cystoscopy (35 and 15 percent, respectively). The test accurately predicted no recurrence for 74 percent of patients who scored negative on the test.

"Given their superior sensitivity and specificity in urine sediments, a combination of hyper- and hypomethylated markers may help avoid unnecessary invasive exams and reveal the importance of DNA methylation in bladder tumorigenesis," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Explore further: Certain genetic variants may put bladder cancer patients at increased risk of recurrence

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Certain genetic variants may put bladder cancer patients at increased risk of recurrence

March 26, 2014
In the Western world, bladder cancer is the fourth most common cancer in men and the eighth most common in women, with many patients experiencing recurrence after treatment. A new study published in BJU International indicates ...

RNA assays up sensitivity of urothelial carcinoma detection

August 21, 2012
(HealthDay) -- Cxbladder, a derivative of the RNA assay uRNA, may be an effective alternative to cytology and nuclear matrix protein 22 (NMP22) assays for the detection of urothelial carcinoma, according to a study published ...

More accurate markers identified for detecting response to epigenetic drugs for myelodysplastic syndromes

April 8, 2013
Researchers have identified and validated two DNA methylation markers that could help physicians to more accurately determine a patient's response to epigenetic drugs for treatment of myelodysplastic syndromes (MDS), according ...

Biomarkers predict time to ovarian cancer recurrence

August 15, 2013
Ovarian cancer often remains undetected until it is at an advanced stage. Despite positive responses to initial treatment, many patients are at risk of tumor recurrence. A multitude of genetic markers have been implicated ...

Low rates of recurrence with 'no ink' as margin in breast CA

February 14, 2014
(HealthDay)—Positive margins (ink on invasive carcinoma or ductal carcinoma in situ) are associated with increased risk of ipsilateral breast tumor recurrence (IBTR), according to consensus guidelines published online Feb. ...

Unique genetic marker may improve detection of recurrent ovarian cancer

December 7, 2011
Ovarian cancer is a major health concern for women and the identification of sensitive biomarkers for early detection and/or monitoring of disease recurrence is of high clinical relevance.

Recommended for you

No dye: Cancer patients' gray hair darkened on immune drugs

July 21, 2017
Cancer patients' gray hair unexpectedly turned youthfully dark while taking novel drugs, and it has doctors scratching their heads.

Shooting the achilles heel of nervous system cancers

July 20, 2017
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center ...

Molecular changes with age in normal breast tissue are linked to cancer-related changes

July 20, 2017
Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history. However, the underlying biologic mechanisms through ...

Immune-cell numbers predict response to combination immunotherapy in melanoma

July 20, 2017
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco ...

Discovery could lead to better results for patients undergoing radiation

July 19, 2017
More than half of cancer patients undergo radiotherapy, in which high doses of radiation are aimed at diseased tissue to kill cancer cells. But due to a phenomenon known as radiation-induced bystander effect (RIBE), in which ...

Definitive genomic study reveals alterations driving most medulloblastoma brain tumors

July 19, 2017
The most comprehensive analysis yet of medulloblastoma has identified genomic changes responsible for more than 75 percent of the brain tumors, including two new suspected cancer genes that were found exclusively in the least ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.