Enhancing the immune response through next generation polymeric vaccine adjuvants

April 3, 2014
The easily modifiable properties of polymers and their potential for functionalization, shown in blue and red respectively, make them attractive candidates for replacing conventional adjuvants. Credit: Technology journal

Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to pathogens. Adjuvants are especially necessary to boost the immune response for subunit vaccines. However, conventional adjuvants are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

The great success of vaccines over the past two centuries as a has led to a significant reduction in morbidity and death caused by controllable infectious diseases. The effectiveness of vaccines is dependent on their ability to induce a protective immune response in recipients. Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to patho-gens. Adjuvants are especially necessary to boost the for subunit vac-cines. However, conventional are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

This review article appearing in Technology and submitted by researchers from Iowa State University investigates the potential of polymeric adjuvants, both natural and synthetic. In addition to a comprehensive study of their use in vaccines, this article sum-marizes the benefits and challenges associated with the use of these polymer systems as adjuvants.

Explore further: Protein serves as a natural boost for immune system fight against tumors

More information: www.worldscientific.com/doi/pd … 42/S2339547814300017

Related Stories

Protein serves as a natural boost for immune system fight against tumors

January 30, 2014
Substances called adjuvants that enhance the body's immune response are critical to getting the most out of vaccines. These boosters stimulate the regular production of antibodies—caused by foreign substances in the body—toxins, ...

Vaccine adjuvant uses host DNA to boost pathogen recognition

April 5, 2013
Aluminum salts, or alum, have been injected into billions of people as an adjuvant to make vaccines more effective. No one knows, however, how they boost the immune response. In the March 19, 2013, issue of the Proceedings ...

Adjuvant combo shows potential for universal influenza vaccine

June 8, 2011
Researchers at National Jewish Health have discovered how to prime a second arm of the immune system to potentially boost influenza vaccine effectiveness. A combination of two adjuvants, chemicals used to boost the effectiveness ...

Compound boosts effect of vaccines against HIV and flu

August 26, 2012
(Medical Xpress)—Oxford University scientists have discovered a compound that greatly boosts the effect of vaccines against viruses like flu, HIV and herpes in mice.

Research describes advantages of new vaccine adjuvant

December 12, 2011
New research from the laboratory of Dr. Elizabeth Leadbetter at the Trudeau Institute may lead to a whole new class of vaccines. Dr. Leadbetter's lab has discovered new properties of a potential vaccine adjuvant that suggest ...

Recommended for you

Genetic immune deficiency could hold key to severe childhood infections

July 18, 2017
A gene mutation making young children extremely vulnerable to common viruses may represent a new type of immunodeficiency, according to a University of Queensland researcher.

What are the best ways to diagnose and manage asthma?

July 18, 2017
What are the best ways to diagnose and manage asthma in adults? This can be tricky because asthma can stem from several causes and treatment often depends on what is triggering the asthma.

Large multi-ethnic study identifies many new genetic markers for lupus

July 17, 2017
Scientists from an international consortium have identified a large number of new genetic markers that predispose individuals to lupus.

Study finds molecular explanation for struggles of obese asthmatics

July 17, 2017
A large, bouquet-shaped molecule called surfactant protein A, or SP-A, may explain why obese asthma patients have harder-to-treat symptoms than their lean and overweight counterparts, according to a new study led by scientists ...

Team identifies potential cause for lupus

July 14, 2017
Leading rheumatologist and Feinstein Institute for Medical Research Professor Betty Diamond, MD, may have identified a protein as a cause for the adverse reaction of the immune system in patients suffering from lupus. A better ...

Immunosuppression underlies resistance to anti-angiogenic therapy

July 14, 2017
A Massachusetts General Hospital (MGH) research team has identified a novel mechanism behind resistance to angiogenesis inhibitors - drugs that fight cancer by suppressing the formation of new blood vessels. In their report ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.