Vitamin D supplementation may be beneficial in depression

April 7, 2014
Vitamin D supplementation may be beneficial in depression

(HealthDay)—Vitamin D supplementation has no overall effect on depressive symptoms, but may have a significant effect for those with clinically significant depression, according to a review published online March 14 in Psychosomatic Medicine.

Jonathan A. Shaffer, Ph.D., from the Columbia University Medical Center in New York City, and colleagues conducted a systematic review to identify randomized trials that compared the effect of vitamin D supplementation with a control condition on depression or . Seven trials, involving 3,191 participants, were included in the analyses.

The researchers found that despite considerable heterogeneity there was no overall effect for vitamin D supplementation on depressive symptoms (standardized mean difference [SMD], −0.14; P = 0.16). For participants with clinically significant depressive symptoms or , vitamin D supplementation had a moderate, statistically significant effect (two studies: SMD, −0.60; P = 0.046), while the effect was small and nonsignificant for those without clinically significant depression (five studies: SMD, −0.04; P = 0.61). The risk of bias was unclear or high in most trials.

"Vitamin D supplementation may be effective for reducing depressive symptoms in patients with clinically significant depression; however, further high quality research is needed," the authors write.

Explore further: Study finds no evidence that vitamin D supplements reduce depression

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Teens unlikely to be harmed by moderate digital screen use

January 13, 2017

Parents and pediatricians alike may worry about the effects of teens' screen time, but new findings from over 120,000 adolescents in the UK indicate that the relationship between screen time and well-being is weak at best, ...

Schizophrenia could directly increase risk of diabetes

January 12, 2017

People with early schizophrenia are at an increased risk of developing diabetes, even when the effects of antipsychotic drugs, diet and exercise are taken out of the equation, according to an analysis by researchers from ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.