Engineered bacteria keep mice lean

mice
Credit: Martha Sexton/public domain

Obesity levels are rising throughout the world. As obesity rates increase, so do the incidences of diabetes, heart disease, and other serious health conditions.

The bacteria within an individual's gut can influence their susceptibility to these disorders. Therefore, altering the microbe population in the gut could prevent or reverse disease.

A June 24th study in the Journal of Clinical Investigation demonstrates that modified bacteria can prevent weight gain in mice. Sean Davies and colleagues at Vanderbilt University made bacteria that produce a compound called NAPE, which signals to the brain to stop eating.

Mice that consumed NAPE-producing bacteria in their water ate less when given high fat food, which limited and associated symptoms.


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Researchers further understanding of how gut bacteria regulate weight gain

More information: Paper: Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity, J Clin Invest. DOI: 10.1172/JCI72517
Citation: Engineered bacteria keep mice lean (2014, June 24) retrieved 22 October 2020 from https://medicalxpress.com/news/2014-06-bacteria-mice.html
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