Exposure to fungicide, tolyfluanid, disrupts energy metabolism

June 23, 2014, The Endocrine Society

Mice exposed to the fungicide tolyfluanid (TF) showed metabolic changes similar to those that signify the development of the metabolic syndrome. The results, which were presented Sunday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.

Metabolic syndrome is a cluster of conditions including increased blood pressure, level, excess body fat around the waist and abnormal . Together these conditions increase the risk of heart disease, stroke and diabetes.

Rates of occurrence of metabolic diseases such as obesity and diabetes are continuing to increase worldwide. Although poor diet and lack of physical activity are primary causes of the majority of metabolic disease, environmental factors have increasingly been implicated as important contributing causes that may increase the risks of developing metabolic diseases brought on by lifestyle.

"Recently, the attention of scientists has been attracted to endocrine-disrupting chemicals (EDCs), compounds that are suspected of promoting the development of various metabolic disorders via their capacity to impact hormonal and metabolic signaling pathways," said lead author Shane Regnier, a doctoral candidate at the University of Chicago's Committee for Molecular Metabolism & Nutrition. "Our study showed one potential EDC, an agricultural fungicide called tolylfluanid (TF), led to in including accumulation of body fat, disruption of glucose metabolism, and reduction of adipose insulin sensitivity."

Adult male mice that consumed a diet containing TF at 100 ppm for 12 weeks showed the types of changes in fasting blood glucose and adipose accumulation that may signify development of . In a separate study, mice were exposed to TF only during fetal development and as newborns. When examined at the time of weaning, the young mice displayed reduced body weight, a symptom that has been associated with an increased risk of metabolic disease later in life. These mice were followed to adulthood, and, although experiencing no further contact with TF, male mice that had been exposed only before and immediately after birth nevertheless displayed impaired glucose tolerance as adults.

The results of these two studies suggest that exposure to TF may promote the development of in humans. While TF levels have been measured in some food crops, in agricultural runoff, and in ground water, TF levels have not been measured in humans. The authors of the study suggest that the results of their two mouse experiments indicate that efforts should be made to characterize exposure of humans to TF to determine whether similar metabolic impacts are seen in humans and that continued use of TF should be carefully considered.

Although approximately 150,000 unique chemicals are registered with the European Chemicals Agency, most are tested only for acute toxicity and carcinogenic capacity. "We are only beginning to understand the role that human-made chemicals play in causing human disease," said Regnier. "The potential for chronic, low-dose exposure to impact and elicit human disease has only begun to be investigated," he added.

Explore further: PFC exposure may spark metabolic changes in overweight children

Related Stories

PFC exposure may spark metabolic changes in overweight children

February 25, 2014
Overweight children who were exposed to higher levels of perfluorinated chemicals tended to show early signs of developing the metabolic syndrome, according to a new study published in The Endocrine Society's Journal of Clinical ...

Inflammation in fat tissue helps prevent metabolic disease

June 18, 2014
Chronic tissue inflammation is typically associated with obesity and metabolic disease, but new research from UT Southwestern Medical Center now finds that a level of "healthy" inflammation is necessary to prevent metabolic ...

Gene behind unhealthy adipose tissue identified

May 22, 2014
Researchers at Karolinska Institutet in Sweden have for the first time identified a gene driving the development of pernicious adipose tissue in humans. The findings imply, which are published in the scientific journal Cell ...

Metabolic syndrome is similar in different age groups

February 13, 2014
Metabolic risk factors cluster similarly in children and adults, according to a study carried out at the University of Eastern Finland. Furthermore, in adults, the clustering of these risk factors increases the risk of premature ...

Fatty liver disease prevented in mice

June 3, 2014
(Medical Xpress)—Studying mice, researchers have found a way to prevent nonalcoholic fatty liver disease, the most common cause of chronic liver disease worldwide. Blocking a path that delivers dietary fructose to the liver ...

The ICEMAN study: How keeping cool could spur metabolic benefits

June 22, 2014
A new study being presented today at ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago, demonstrates that ambient temperatures can influence the growth or ...

Recommended for you

Forces from fluid in the developing lung play an essential role in organ development

January 23, 2018
It is a marvel of nature: during gestation, multiple tissue types cooperate in building the elegantly functional structures of organs, from the brain's folds to the heart's multiple chambers. A recent study by Princeton researchers ...

More surprises about blood development—and a possible lead for making lymphocytes

January 22, 2018
Hematopoietic stem cells (HSCs) have long been regarded as the granddaddy of all blood cells. After we are born, these multipotent cells give rise to all our cell lineages: lymphoid, myeloid and erythroid cells. Hematologists ...

How metal scaffolds enhance the bone healing process

January 22, 2018
A new study shows how mechanically optimized constructs known as titanium-mesh scaffolds can optimize bone regeneration. The induction of bone regeneration is of importance when treating large bone defects. As demonstrated ...

Researchers illustrate how muscle growth inhibitor is activated, could aid in treating ALS

January 19, 2018
Researchers at the University of Cincinnati (UC) College of Medicine are part of an international team that has identified how the inactive or latent form of GDF8, a signaling protein also known as myostatin responsible for ...

Bioengineered soft microfibers improve T-cell production

January 18, 2018
T cells play a key role in the body's immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, ...

Weight flux alters molecular profile, study finds

January 17, 2018
The human body undergoes dramatic changes during even short periods of weight gain and loss, according to a study led by researchers at the Stanford University School of Medicine.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.